Results 51 to 60 of about 28,700 (263)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Global profiling of N6‐methyladenosine methylation in maize callus induction

The Plant Genome, 2020
Callus induction is a dedifferentiation process that accompanies a cell fate transition, and epigenetic regulation plays a crucial role in the process.
Xuemei Du, Ting Fang, Yan Liu, Meng Wang, Maosen Zang, Liying Huang, Sihan Zhen, Jie Zhang, Zichen Shi, Guoying Wang, Junjie Fu, Yunjun Liu   +11 more
doaj   +1 more source

Epigenetic Regulation of m6A Modifications in Human Cancer

Molecular Therapy: Nucleic Acids, 2020
N6-methyladenosine (m6A) is the most prevalent internal RNA modification, especially within eukaryotic messenger RNAs (mRNAs). m6A modifications of RNA regulate splicing, translocation, stability, and translation into proteins.
Wei Zhao, Xiaoqian Qi, Lina Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +5 more
doaj   +1 more source

Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives [PDF]

, 2021
Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors.
Biancari, Fausto, Blokhina, Daria, Bäckström, Pia, Dahlbacka, Sebastian, Elomaa, Outi, Eskin, Arda, Jormalainen, Mikko, Juvonen, Tatu, Kaarne, Markku, Kankuri, Esko, Karelson, Mati, Karjalainen, Pasi, Katayama, Shintaro, Khan, Jahangir, Kiss, Jan, Koivisto, Pertti, Laine, Mika, Lalowski, Maciej, Laurikka, Jari, Lemström, Karl, Mervaala, Eero, Nummi, Annu, Nykänen, Antti, Oksaharju, Kati, Raivio, Peter, Rajala, Helena, Ropponen, Jussi, Savinainen, Kimmo, Sikorski, Vilbert, Simpanen, Jarmo, Stark, Christoffer, Suihko, Satu, Syrjälä, Simo, Teittinen, Kari, Tuncbag, Nurcan, Tuohinen, Suvi, Vainikka, Tiina, Vento, Antti, Vähäsilta, Tommi   +38 more
core   +6 more sources

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]

, 2016
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
A Hilfiker, B Moindrot, C Church, C Schütt, C Trapnell, CF Hongay, D Dominissini, D Kim, D Sturgill, D Yan, DP Patil, E Zaharieva, Eugenio Sanchez-Moran, GZ Luo, Helen K. Salz, Irmgard U. Haussmann, IU Haussmann, IU Haussmann, IU Haussmann, J Liu, J Zhou, JA Bokar, JE Harper, JT Robinson, K Horiuchi, KD Meyer, KD Meyer, KJ Livak, LO Penalva, M Niessen, M Soller, M Soller, M Soller, Matthias Soller, Nathan Archer, Nigel P. Mongan, RP Perry, Rupert G. Fray, S Geula, S Ke, S Luo, S Schwartz, S Zhong, SR Starck, W Xiao, X Wang, Z Bodi, Z Bodi, Zsuzsanna Bodi   +48 more
core   +5 more sources

Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review [PDF]

, 2022
BACKGROUND AND OBJECTIVE: The recent emergence of epitranscriptomics provides an avenue for identifying RNA modifications implicated in the pathophysiology of human disease.
Ilieva, Mirolyuba Simeonova, Uchida, Shizuka   +1 more
core   +1 more source

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

Molecular Therapy: Nucleic Acids, 2020
N6-Methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) that occurred on the N6 nitrogen of adenosine. However, the roles of m6A in oral squamous cell carcinoma (OSCC) are still elusive.
Wei Zhao, Yameng Cui, Lina Liu, Xiaozhou Ma, Xiaoqian Qi, Yue Wang, Zihao Liu, Shiqing Ma, Jingwen Liu, Jie Wu   +9 more
doaj   +1 more source

Systematic comparison of tools used for m6A mapping from nanopore direct RNA sequencing

Nature Communications, 2023
Direct RNA sequencing using nanopore platform can be used to detect N6-methyladenosine (m6A) modifications on mRNAs. Here the authors systematically compare tools used for m6A detection from nanopore direct sequencing.
Zhen-Dong Zhong, Ying-Yuan Xie, Hong-Xuan Chen, Ye-Lin Lan, Xue-Hong Liu, Jing-Yun Ji, Fu Wu, Lingmei Jin, Jiekai Chen, Daniel W. Mak, Zhang Zhang, Guan-Zheng Luo   +11 more
doaj   +1 more source