Results 51 to 60 of about 17,313 (241)

The RNA N6‐methyladenosine demethylase ALKBH9B modulates ABA responses in Arabidopsis

Journal of Integrative Plant Biology, Volume 64, Issue 12, Page 2361-2373, December 2022., 2022
The RNA m6A demethylase ALKBH9B removes m6A from the ABSCISIC ACID (ABA) INSENSITIVE 1 (ABI1) and BRI1‐EMS‐SUPPRESSOR 1 (BES1) transcripts, thus stabilizing them and leading to the inhibition of ABI3 and ABI5 by ABI1 and BES1 proteins, promoting seed germination and early seedling development under ABA treatment.
Jun Tang, Junbo Yang, Qiang Lu, Qian Tang, Shuyan Chen, Guifang Jia   +5 more
wiley   +1 more source

The N6-Methyladenosine RNA modification in pluripotency and reprogramming [PDF]

Current Opinion in Genetics & Development, 2017
Chemical modifications of RNA provide a direct and rapid way to manipulate the existing transcriptome, allowing rapid responses to the changing environment further enriching the regulatory capacity of RNA. N6-Methyladenosine (m6A) has been identified as the most abundant internal modification of messenger RNA in eukaryotes, linking external stimuli to ...
Francesca Aguilo, Francesca Aguilo, Martin J. Walsh   +2 more
openaire   +3 more sources

N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]

Molecular Cell, 2018
N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Qin Yang, Chu-Xiao Liu, Ling-Ling Chen, Ling-Ling Chen, Man Wu, Li Yang, Li Yang, Jian-Feng Xiang   +7 more
openaire   +3 more sources

Mechanism of RNA modification N6-methyladenosine in human cancer [PDF]

Molecular Cancer, 2020
AbstractSince the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a predominantly internal epigenetic modification in eukaryotes mRNA, heralded the creation of the field of epi-transcriptomics.
Zijian Zhou, Jiancheng Lv, Hao Yu, Jie Han, Xiao Yang, Dexiang Feng, Qikai Wu, Baorui Yuan, Qiang Lu, Haiwei Yang   +9 more
openaire   +4 more sources

N6-methyladenosine Modification in Bacterial mRNA [PDF]

Clinical Microbiology: Open Access, 2016
Among more than 140 naturally occurring RNA modifications have been identified, N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification in eukaryotic organisms. A group of demethylases, methyltransferase and m6A-specific binding proteins in mammals, plants as well as yeast are in support of the regulatory functions of this RNA ...
Xin Deng, Xiaolong Shao, Heng Shi, Yingchao Zhang, Ruxia Gao   +4 more
openaire   +1 more source

Association of N6-methyladenosine with viruses and related diseases

Virology Journal, 2019
AbstractBackgroundN6-methyladenosine (m6A) modification is the most prevalent internal modification of eukaryotic mRNA modulating gene expression. m6A modification is a dynamic reversible process regulated by three protein groups: methyltransferases (writers), demethylases (erasers), and m6A-binding proteins (readers).
Mingqing Tang, Ruian Xu, Yong Diao, Wenzhao Cheng, Wenzhao Cheng, Fang Wu, Feiyuan Zhao   +6 more
openaire   +4 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4

Nature Communications, 2022
Here the authors combine functional and structural work to show that METTL4 functions as U2 snRNA m6Am RNA methyltransferase supporting N6-methylation of 2’-O-methyladenosine in Arabidopsis.
Qiang Luo, Jiezhen Mo, Hao Chen, Zetao Hu, Baihui Wang, Jiabing Wu, Ziyu Liang, Wenhao Xie, Kangxi Du, Maolin Peng, Yingping Li, Tianyang Li, Yangyi Zhang, Xiaoyan Shi, Wen-Hui Shen, Yang Shi, Aiwu Dong, Hailin Wang, Jinbiao Ma   +18 more
doaj   +1 more source

Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors

Advanced Therapeutics, EarlyView.
Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe, Jacobus Burger, Jamie Jones, Apurva Panjla, William L. Murphy   +4 more
wiley   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source