Results 91 to 100 of about 54,300 (231)

Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications.

PLoS ONE, 2019
RNA contains various chemical modifications, among which N6-methyladenosine (m6A) is the most prevalent modified nucleotide in eukaryotic mRNA. Emerging evidence suggests that m6A plays an important role in regulating a variety of cellular functions by ...
Shun Matsuzawa, Yuka Wakata, Fumiya Ebi, Masaharu Isobe, Nobuyuki Kurosawa   +4 more
doaj   +1 more source

Data_Sheet_1_RNA N6-Methyladenosine-Related Gene Contribute to Clinical Prognostic Impact on Patients With Liver Cancer.pdf

, 2020
Liver cancer (LC) is the fourth leading cause of cancer-related deaths worldwide. There is an urgent need to identify novel and reliable prognostic biomarkers for LC in order to improve patient outcomes.
Bo Sun (177052), Shenghong Sun (8750763), Chiyi He (8750766), Wei Wang (17594), Yang Xia (104600)   +4 more
core   +1 more source

SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition

Advanced Science, EarlyView.
The SEC promotes cell identity transitions by facilitating transcription pause release at key identity‐associated genes, including Klf4 and Myc during iPSC reprogramming and Nes and Tubb3 during ESC‐to‐neuroectodermal differentiation. During early iPSC reprogramming, this function additionally involves cooperation with METTL3‐associated m6A regulation.
Zhijing Zhang, Jingyi Xu, Yonghong Wu, Yitong Qu, Xinglin Hu, Yuchen Sun, Yanshuang Wu, Zhonghua Liu, Jiaqiang Wang, Lei Lei   +9 more
wiley   +1 more source

Dot Blot Analysis of N6-methyladenosine RNA Modification Levels

Bio-Protocol, 2017
N6-methyladenosine (m6A) is the most prevalent internal modification of eukaryotic messenger RNA (mRNA). The total amount of m6A can be detected by several methods, such as dot blot analysis using specific m6A antibodies and quantitative liquid ...
Lisha Shen, Zhe Liang , Hao Yu
doaj   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Image_2_Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients.tif

, 2022
N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC).
Zhejun Deng (12791090), Xianbin Wu (12791087), Lixing Pang (12791096), Xiaomin Liao (11147295), Haixing Jiang (8507154), Nanfang Qu (8507145), Xianxian Ruan (12791093), Shanyu Qin (12259896), Xiaoyan Shi (156294)   +8 more
core   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Functions of N6-methyladenosine and its role in cancer

Molecular Cancer, 2019
N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA.
Liuer He, Huiyu Li, Anqi Wu, Yulong Peng, Guang Shu, Gang Yin   +5 more
doaj   +1 more source

Data_Sheet_2_RNA N6-Methyladenosine-Related Gene Contribute to Clinical Prognostic Impact on Patients With Liver Cancer.xlsx

, 2020
Liver cancer (LC) is the fourth leading cause of cancer-related deaths worldwide. There is an urgent need to identify novel and reliable prognostic biomarkers for LC in order to improve patient outcomes.
Bo Sun (177052), Shenghong Sun (8750763), Chiyi He (8750766), Wei Wang (17594), Yang Xia (104600)   +4 more
core   +1 more source

Image_1_Establishment of Prognostic Signatures of N6-Methyladenosine-Related lncRNAs and Their Potential Functions in Hepatocellular Carcinoma Patients.tif

, 2022
N6-methyladenosine (m6a)-related mRNAs and lncRNAs have been explored for their functions in several cancers. The present study aimed to identify potential signatures of m6a-related lncRNAs in hepatocellular carcinoma (HCC).
Zhejun Deng (12791090), Xianbin Wu (12791087), Lixing Pang (12791096), Xiaomin Liao (11147295), Haixing Jiang (8507154), Nanfang Qu (8507145), Xianxian Ruan (12791093), Shanyu Qin (12259896), Xiaoyan Shi (156294)   +8 more
core   +1 more source