Results 181 to 190 of about 5,820,024 (228)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Accessibility of Digital Financial Applications for People With Visual Impairment: Scoping Review. [PDF]

J Med Internet Res
Puli L, Kooijman L, Kanij T, Hartel C, Shahriar AZM, Rotaru K.   +5 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Molecular Characterization and Antibiotic Resistance of Broad-Spectrum <i>β</i>-Lactamase-Producing Enterobacterales in Urinary Tract Infections in Libreville, Gabon. [PDF]

Int J Microbiol
Yala JF, Minko OZ, Mabika RM, Mounioko F, Mbongo-Kama EA, Dikoumba AC, Souza A.   +6 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Status for and associations between disability, employment, barriers for work and health-related quality of life in individuals with multiple sclerosis: A cross-sectional study. [PDF]

Mult Scler J Exp Transl Clin
Arntzen EC, Fikke HK, Sivertsen M, Normann B.   +3 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Patient experience after pelvic exenteration: chronic pain and quality of life. [PDF]

Support Care Cancer
Louis O, Young J, Power C, Atkin C, Behrenbruch C.   +4 more
europepmc   +1 more source