Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Live bovine animal export dynamics and structural heterogeneity across European member states, 2014-2024: A cluster -based analysis. [PDF]
Skujina E, Pilvere I.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Patient Perspectives on Electronic Communication of Cancer Diagnoses.
Bhalla S +9 more
europepmc +1 more source
Immune checkpoint inhibitor neurotoxicity: long-term outcomes with focus on 1-year neurological sequelae. [PDF]
Farina A +13 more
europepmc +1 more source
Allopurinol has no effect on calcitriol or other CKD-MBD biomarkers: a randomized double-blind study. [PDF]
Costa TE +7 more
europepmc +1 more source
Induction and Prolonged Induction With Mirikizumab in Ulcerative Colitis-A Prospective, Real-World Study From the Sicilian Network for Inflammatory Bowel Disease (SN-IBD). [PDF]
Costantino G +24 more
europepmc +1 more source
Assessment of Ocular Surface Pathogen Susceptibility to Ultraviolet-C (UVC) Light Treatment With a Novel Prototype Device-An In Vitro Study. [PDF]
Williams OJ +3 more
europepmc +1 more source
Mac-2 binding protein glycosylation isomer contributes to identify advanced Fontan-associated liver disease: A retrospective cohort study. [PDF]
Kitsugi K +9 more
europepmc +1 more source

