Results 81 to 90 of about 49,721 (234)

Achievement of the Ideal Outcome After Pancreatectomy for Pancreatic Ductal Adenocarcinoma Is Associated With Earlier Initiation and Higher Completion Rates of Adjuvant Chemotherapy and Improved Long‐Term Survival

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Ideal Outcome is a composite quality indicator reflecting optimal postoperative course after pancreatic surgery. This study aimed to clarify the prognostic significance of achieving the Ideal Outcome and its influence on the initiation and completion of adjuvant chemotherapy.
Ryosuke Fukushima, Kenichiro Araki, Ryo Muranushi, Kouki Hoshino, Kei Hagiwara, Shunsuke Kawai, Mariko Tsukagoshi, Takamichi Igarashi, Norio Kubo, Ken Shirabe   +9 more
wiley   +1 more source

Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study

Pharmaceuticals, 2020
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid ...
Claire V. Cawthon, Kathryn Cooper, Clifton Huett, Alyssa Lloret, Estefanny Villar-Matamoros, Lauren Stokes, Uwe Christians, Michele Schuler, Saami K. Yazdani   +8 more
doaj   +1 more source

Atezolizumab and nab-paclitaxel in advanced triple-negative breast cancer

, 2018
BACKGROUND Unresectable locally advanced or metastatic triple-negative (hormone-receptor-negative and human epidermal growth factor receptor 2 [HER2]-negative) breast cancer is an aggressive disease with poor outcomes.
Rugo, H. S., Hegg, R., Husain, A., Schneeweiss, A., Wright, G. Shaw, Henschel, V., Im, S. -A., Schmid, P., Adams, S., Chui, S. Y., Loi, S., Funke, R., Emens, L. A., Dieras, V., Iwata, H., Barrios, C. H., Winer, E. P., Molinero, L.   +17 more
core   +1 more source

Randomized phase II study of nab-paclitaxel as first-line chemotherapy in patients with HER2-negative metastatic breast cancer [PDF]

, 2017
Weekly administration of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) has been shown to be a safe and effective treatment for metastatic breast cancer (MBC) in clinical studies.
Nakayama, Takahiro, Yamauchi, Hideko, Junichiro Watanabe, Masuda, Norikazu, Hitoshi Arioka, Takanori Ishida, Inoue, Kenichi, Takao, Shintaro, Toyama, Tatsuya, Tokuda, Yutaka, Hiroshi Ishiguro, Norikazu Masuda, Yutaka Tokuda, Nobuaki Sato, Masahiro Kashiwaba, Tatsuya Toyama, Sato, Nobuaki, Ishiguro, Hiroshi, Saeki, Toshiaki, Yamada, Kimito, Kenichi Inoue, Shinji Ohno, Hiroji Iwata, Tamura, Kenji, Saito, Mitsue, Fujiwara, Yasuhiro, Kenji Tamura, Arioka, Hitoshi, Toshiaki Saeki, Hideko Yamauchi, Aogi, Kenjiro, Kashiwaba, Masahiro, Shintaro Takao, Naohito Yamamoto, Ishida, Takanori, Kimito Yamada, Watanabe, Junichiro, Iwata, Hiroji, Takahiro Nakayama, Kenjiro Aogi, Ohno, Shinji, Mitsue Saito, Yasuhiro Fujiwara, Yamamoto, Naohito   +43 more
core   +1 more source

Pharmacogenomic profiling of the efficacy of gemcitabine monotherapy in metastatic pancreatic cancer: Subgroup analysis of the GENESECT study

British Journal of Clinical Pharmacology, EarlyView.
Aim In the GENESECT study, no significant gemcitabine (GEM) metabolism‐related germline genetic polymorphisms (GPs) were identified because approximately 70% of patients received combination therapy with nab‐paclitaxel, which has metabolic pathways different from GEM.
Takashi Yokokawa, Daiki Tsuji, Masahiro Hatori, Kazuyoshi Kawakami, Masahiko Nakao, Takuya Yano, Yuichiro Arakawa, Keisuke Matsuo, Yasukata Ohashi, Masato Ozaka, Naoki Sasahira, Yasuhiko Sakata, Yuki Kogure, Shinya Tamaki, Atsushi Wada, Yusuke Taki, Wataru Suzuki, Kazuo Kobayashi, Hiroshi Ishii, Kunihiko Itoh, Masakazu Yamaguchi, Kenichi Suzuki   +21 more
wiley   +1 more source

De‐Escalation of Neoadjuvant Treatment for HER2‐Positive Breast Cancer

International Journal of Cancer, EarlyView.
ABSTRACT With improved prognosis in early HER2‐positive breast cancer, safely de‐escalating treatment is increasingly investigated to minimize overtreatment. This article focuses on neoadjuvant de‐escalation strategies for HER2‐positive breast cancer.
Yiyin Ma, Dedian Chen, Sheng Huang
wiley   +1 more source

Cisplatin improves antitumor activity of weekly nab-paclitaxel in patients with metastatic breast cancer

, 2014
Si Sun,1 Lichen Tang,2 Jian Zhang,1 Fangfang Lv,1 Zhonghua Wang,1 Leiping Wang,1 Qunling Zhang,1 Chunlei Zheng,1 Lixin Qiu,1 Zhen Jia,1 Yunhua Lu,1 Guangyu Liu,2 Zhimin Shao,2 Biyun Wang,1 Xichun Hu1 1Department of Medical Oncology, Fudan University ...
Zhang J, Wang B, Lu Y, Hu X, Zhang Q, Wang L, Qiu L, Tang L, Lv F, Shao Z, Sun S, Zheng C, Wang Z, Jia Z, Liu G   +14 more
core  

Preoperative treatment with gemcitabine plus nab-paclitaxel is a safe and effective chemotherapy for pancreatic adenocarcinoma

, 2016
Introducción: Recientemente, nuevos agentes quimioterapéuticos como nab-paclitaxel y gemcitabina han demostrado un beneficio en la supervivencia en comparación con la gemcitabina sola en el cáncer de páncreas metastásico.
Malavé, Hidalgo, Belpo, B., Vicente, Y, Diaz, Fabra,, Quijano, Y., Caruso, Ferri,, Plaza Hernández, José Carlos   +6 more
core   +1 more source

Aumolertinib Versus Osimertinib as First‐Line Treatment for EGFR‐Mutant Non‐Small Cell Lung Cancer: A Retrospective Real‐World Multicenter Study

International Journal of Cancer, EarlyView.
As third‐generation EGFR‐tyrosine kinase inhibitors, both aumolertinib and osimertinib demonstrate clinical efficacy for non‐small cell lung adenocarcinoma, especially in patients with brain metastases. Currently, head‐to‐head studies comparing these two agents in real‐world settings are scarce.
Jinxia Wang, Ping Qi, Jinhua Li, Na Wang, Caihong Fu, Lixin Liu, Shuping Li, Xiao Li, Xiaoming Hou, Hui Qiao   +9 more
wiley   +1 more source

Effect of intrapleural anti-Vascular Endothelial Growth Factor (VEGF) associated with nab paclitaxel in a murine model of malignant pleural effusion

BMC Cancer
Background Malignant pleural effusion (MPE) is a disease associated with poor prognosis, high morbidity, and significant mortality. Murine models of MPE have successfully replicated its formation and metastases, providing valuable insights into potential
Carlos Sergio Rocha Silva, Lisete Ribeiro Teixeira, Karina Rocha Pereira, Philippe Figueiredo Braga Colares, Vanessa Adelia Alvarenga, Roberta Karla Barbosa Sales, Amanda Cabral Roque, Evaldo Marchi, Ronei Luciano Mamoni, Milena Marques Pagliarelli Acencio   +9 more
doaj   +1 more source