Results 101 to 110 of about 49,721 (234)

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Evaluation of combination treatment benefits of nab-paclitaxel in experimental pancreatic cancer.

, 2012
170 Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human cancers and is characterized by early tissue invasion, metastasis and high resistance to systemic therapies.
Changhua Zhang, Niranjan Awasthi, Katherine Ostapoff, Margaret A. Schwarz, Roderich Schwarz   +4 more
core   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

nab-Paclitaxel: Novel Clinical and Experimental Evidence in Pancreatic Cancer

, 2014
The past few decades have seen virtually no treatment advances for patients with metastatic pancreatic cancer. Clinical hallmark features of pancreatic ductal adenocarcinoma (PDA) include late symptom onset, invasive growth, early liver and lymph node ...
Neesse, A., Michl, P., Tuveson, D. A., Ellenrieder, V.   +3 more
core   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

SAKK57/16 Nab-paclitaxel and Gemcitabine in Soft Tissue Sarcoma (NAPAGE): a phase I/II trial. [PDF]

BACKGROUND To determine whether the combination of nab-paclitaxel with gemcitabine has activity in patients with pretreated soft tissue sarcoma (STS).
Digklia, A., Kronig, M.N., Colombo, I., Colombo, I, Dietrich, D., Kollár, A, Rordorf, T, Krasniqi, F, Kollár, A., Kronig, M N, Metaxas, Y, Rothermundt, C, Britschgi, C., Ribi, K., Rordorf, T., Digklia, A, Rothermundt, C., Ribi, K, Joerger, M., Britschgi, C, Krasniqi, F., Metaxas, Y., Dietrich, D, Joerger, M   +23 more
core   +2 more sources

Atezolizumab (In Combination With Nab-Paclitaxel): A Review in Advanced Triple-Negative Breast Cancer

, 2020
Compliance with Ethical StandardsFunding The preparation of this review was not supported by any external funding.Conflicts of interest Connie Kang and Yahiya Y.
Connie Kang (7248215), Yahiya Y. Syed (6594444)   +1 more
core   +1 more source

Synergy of Nab-paclitaxel and Bevacizumab in Eradicating Large Orthotopic Breast Tumors and Preexisting Metastases [PDF]

, 2011
Introduction Patients with metastatic disease are considered incurable. We previously showed that nabpaclitaxel (nanoparticle albumin-embedded paclitaxel) combined with anti-vascular endothelial growth factor A (VEGF-A) antibody, bevacizumab, eradicates ...
Trieu, Vuong, Vuong Trieu, Sophia Ran, Neil Desai, Ran, Sophia, Flister, Michael J., Lisa D. Volk, Deena Chihade, Chihade, Deena, Volk, Lisa D., Michael J. Flister, Desai, Neil   +11 more
core   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Augmentation of Nab-Paclitaxel Chemotherapy Response by Mechanistically Diverse Antiangiogenic Agents in Preclinical Gastric Cancer Models

, 2018
Gastric adenocarcinoma (GAC) remains the third most common cause of cancer-related deaths worldwide. Systemic chemotherapy is commonly recommended as a fundamental treatment for metastatic GAC; however, standard treatment has not been established yet ...
Schwarz, Margaret A., Awasthi, Niranjan, Zhang, Changhua, Schwarz, Roderich E.   +3 more
core   +1 more source