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Identification of the Aedes aegypti nAChR gene family and molecular target of Spinosad.
Pest Management Science, 2020BACKGROUND Spinosad is an insecticide with unique mode of action (MOA) of disrupting nicotinic acetylcholine receptor and efficacious against many insect species.
Jianqiang Lan +8 more
semanticscholar +1 more source
Nicotine: A Targeted Therapy for Epilepsy Due to nAChR Gene Variants
Journal of Child Neurology, 2020Objective: Genetic variants of the neuronal nicotinic acetylcholine receptor (nAChR) cause autosomal dominant sleep-related hypermotor epilepsy. Approximately 30% of autosomal dominant sleep-related hypermotor epilepsy patients are medically intractable.
Jordana Fox, D. Thodeson, Alison Dolce
semanticscholar +1 more source
α5‐nAChR and survivin: Two potential biological targets in lung adenocarcinoma
Journal of Cellular Physiology, 2020Recent studies have shown that the overexpression of α5 nicotinic acetylcholine receptor (α5‐nAChR) is associated with nicotine‐related lung carcinogenesis. Survivin is one of the biomarkers of a worse prognosis for smoking‐related lung cancer.
Yujie Zhang +5 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 2018
Adenocarcinoma and glioblastoma cell lines express α7- and α9α10-containing nicotinic acetylcholine receptors (nAChRs), whose activation promotes tumor cell growth.
F. Bavo +16 more
semanticscholar +1 more source
Adenocarcinoma and glioblastoma cell lines express α7- and α9α10-containing nicotinic acetylcholine receptors (nAChRs), whose activation promotes tumor cell growth.
F. Bavo +16 more
semanticscholar +1 more source

