Results 171 to 180 of about 127,437 (365)

Nicotinamide Riboside: A Promising Treatment for Type 1 Cardiorenal Syndrome in Myocardial Infarction‐Induced Acute Kidney Injury by Upregulating Nicotinamide Phosphoribosyltransferase‐Mediated Nicotinamide Dinucleotide Levels

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiorenal syndrome type 1 is characterized by the development of acute kidney injury following acute cardiac illness and notably acute myocardial infarction (MI).
Nada J. Habeichi, Ghadir Amin, Solene Boitard, Cynthia Tannous, Rana Ghali, Iman Momken, Reine Diab, George W. Booz, Mathias Mericskay, Fouad A. Zouein   +9 more
doaj   +1 more source

The NAD Kinase Slr0400 Functions as a Growth Repressor in Synechocystis sp. PCC 6803 [PDF]

, 2021
Yuuma Ishikawa, Cédric Cassan, Aikeranmu Kadeer, Koki Yuasa, Nozomu J. Sato, Kintake Sonoike, Yasuko Kaneko, Atsuko Miyagi, Hiroko Takahashi, Toshiki Ishikawa, Masatoshi Yamaguchi, Yoshitaka Nishiyama, Yukako Hihara, Yves Gibon, Maki Kawai‐Yamada   +14 more
openalex   +1 more source

Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]

, 2011
Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Polyphosphate-dependent nicotinamide adenine dinucleotide (NAD) kinase: A novel missing link in human mitochondria. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2021
Murata K.
europepmc   +1 more source

Prediction of Small Molecule Kinase Inhibitors for Chemotherapy Using Deep Learning [PDF]

arXiv, 2019
The current state of cancer therapeutics has been moving away from one-size-fits-all cytotoxic chemotherapy, and towards a more individualized and specific approach involving the targeting of each tumor's genetic vulnerabilities. Different tumors, even of the same type, may be more reliant on certain cellular pathways more than others.
arxiv  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Altered metabolism of chloroplastic NAD kinase-overexpressing Arabidopsis in response to magnesium sulfate supplementation. [PDF]

Plant Signal Behav, 2021
Kawai-Yamada M, Miyagi A, Sato Y, Hosoi Y, Hashida SN, Ishikawa T, Yamaguchi M.   +6 more
europepmc   +1 more source

Proline metabolism and NAD kinase activity in soybean calli during short- and long-term exposures to light and NaCl [PDF]

, 1997
Gilles Guerrier, Olivier Delumeau, Michelle Renard, Danielle Laval‐Martin   +3 more
openalex   +1 more source

Cofactor Fingerprinting with STD NMR to Characterize Proteins of Unknown Function: Identification of a Rare cCMP Cofactor Preference [PDF]

, 2004
Proteomics efforts have created a need for better strategies to functionally categorize newly discovered proteins. To this end, we have employed saturation transfer difference NMR with pools of closely related cofactors, to determine cofactor preferences.
Sem, Daniel, Yao, Huili
core   +1 more source