Results 191 to 200 of about 74,916 (255)

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Editorial: Metabolic engineering for the production of bioactive compounds. [PDF]

Front Microbiol
Squina FM, Fernández Perrino FJ, Ahire JJ, Chao YP.   +3 more
europepmc   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Targeting TRAF3IP2 disrupts cellular energetics through inhibition of NAMPT in triple negative breast cancer. [PDF]

Sci Rep
Willingham K, Izadpanah A, Rashad Y, Reilich A, Daneshimehr F, Braun S, Alt EU, Izadpanah R.   +7 more
europepmc   +1 more source

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Noninvasive methods to monitor dynamic single-cell events. [PDF]

Trends Cell Biol
Lee REC, Yeung J, Mumford T, Bugaj L, Daniels MJ, Stanley J, Pourmand N, Vineall KG, Schmitt DL, Rahman SMT, Sung MH.   +10 more
europepmc   +1 more source

Alpha-ketoglutarate accelerates granulocyte-monocyte progenitor differentiation and atherosclerotic plaque inflammation via oxoglutarate receptor 1. [PDF]

Redox Biol
Zhao J, Su L, Li W, Lam SM, Yan C, Zhou T, Deng Y, Dong Y, Zhou Y, Shui G, Feng Y.   +10 more
europepmc   +1 more source

Relevance and application of sirtuin 3-activated mitophagy in gastric cancer treatment. [PDF]

World J Clin Oncol
Zhao HY, Yu CY, Ye XT, Qian ST, Huang Y, Liu QS.   +5 more
europepmc   +1 more source

Advances in synthetic biology for engineering methylotrophic microbial cell factories. [PDF]

J Bacteriol
Guo L, Li R, Gao X, Zhao L, Zhang H.
europepmc   +1 more source