Results 201 to 210 of about 73,229 (276)

Mitochondrial dysfunction in cellular senescence: a bridge to neurodegenerative disease. [PDF]

NPJ Aging
Hruby AJ, Higuchi-Sanabria R.
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Non-Canonical Senescence Phenotype in Resistance to CDK4/6 Inhibitors in ER-Positive Breast Cancer. [PDF]

Biomolecules
Mammadova A, Gu Y, Ruan L, Badve SS, Gökmen-Polar Y.   +4 more
europepmc   +1 more source

A group of L-type lectin receptor kinases function redundantly in mediating extracellular NAD(P) signaling in Arabidopsis [PDF]

Qi Li, M. Zhou, Fiona M. Harris, Zhonglin Mou   +3 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes. [PDF]

Curr Issues Mol Biol
Choi YJ, Kang M, Jin MH, Kim J, Lee WK, Roh SS, Kang KS, Hwang GS, Park S, Lee S.   +9 more
europepmc   +1 more source

A Ca2+, Calmodulin-dependent NAD kinase from corn is located in the outer mitochondrial membrane.

, 1984
Peter Dieter, Dieter Marmé
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Integrating Senescence and Oxidative Stress in Cardiac Disease. [PDF]

Int J Mol Sci
Yun HR, Singh MK, Han S, Ranbhise JS, Ha J, Kim SS, Kang I.   +6 more
europepmc   +1 more source

Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression

, 2019
Justin B. Collier, Rick G. Schnellmann
openalex   +2 more sources