Results 31 to 40 of about 686 (83)

Induction of antiinflammatory purinergic signaling in activated human iNKT cells. [PDF]

, 2018
Invariant natural killer T (iNKT) cells are activated at sites of local tissue injury, or globally during vaso-occlusive episodes of sickle cell disease (SCD). Tissue damage stimulates production of CD1d-restricted lipid antigens that activate iNKT cells
Field, Joshua, Lin, Gene, Linden, Joel, Yu, Jennifer   +3 more
core   +1 more source

Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Antimicrobial peptides (AMPs) are promising alternatives to conventional treatments for polymicrobial biofilms, which increase pathogen resistance. AMPs disrupt biofilm extracellular matrices and microbial membranes, inhibiting biofilm formation and enhancing antibiotic efficacy. Current research addresses challenges like stability and production costs
Cesar Augusto Roque‐Borda, Laura Maria Duran Gleriani Primo, Kaila Petronila Medina‐Alarcón, Isabella C. Campos, Camila de Fátima Nascimento, Mauro M. S. Saraiva, Angelo Berchieri Junior, Ana Marisa Fusco‐Almeida, Maria José Soares Mendes‐Giannini, João Perdigão, Fernando Rogério Pavan, Fernando Albericio   +11 more
wiley   +1 more source

Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase [PDF]

, 2010
Background Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) are promising cancer drugs currently in clinical trials in oncology, including APO866, CHS-828 and the CHS-828 prodrug EB1627/GMX1777, but cancer cell resistance to these drugs has ...
A Formentini, A Garten, A Nahimana, A Ravaud, AA Sauve, Annemette V Thougaard, Antje Garten, C Lengauer, C Mattos, C Schou, F Nomura, Fredrik Björkling, G Kroemer, GB Kang, GC Elliott, GJ Hageman, GJ Peters, J Diefenbach, J Gullbo, JA Khan, JA Khan, Jakob G Petersen, JB Clark, JR Revollo, JR Revollo, JR Revollo, Jun Yoshino, K Holen, LR Saunders, LS Olsen, M Hasmann, M Pishvaian, M Watson, M Ziegler, Maxwell Sehested, MD Jackson, ME Gorre, ME Gorre, Mette K Christensen, MK Kim, P Hovstadius, P Hovstadius, P Martinsson, PA Janne, PB Jensen, Peter B Jensen, Peter Fristrup, PJ Hjarnaa, SB Hassan, Shin-Ichiro Imai, Søren J Nielsen, T O'Hare, T Wang, U Galli, Uffe H Olesen, UH Olesen, UH Olesen, Wieland Kiess   +57 more
core   +5 more sources

Bacterial volatile organic compounds supplemented with light‐emitting diode lighting enhance antioxidant capacity and delay senescence in broccoli

Food Frontiers, Volume 6, Issue 1, Page 448-464, January 2025.
Bacterial volatile organic compounds (BVOCs) are biological volatiles that can have a positive effect on the postharvest preservation of fruits and vegetables. In the present study, fumigation of broccoli with BVOCs released by Lysinibacillus fusiformis supplemented with LED white light irradiation reduced the accumulation of reactive oxygen species ...
Taishan Huang, Junyan Shi, Xiaozhen Yue, Shuzhi Yuan, Xiangbin Xu, Jinhua Zuo, Qing Wang   +6 more
wiley   +1 more source

The Potential of Secondary Metabolites in Medicinal Plants as Anti–Quorum Sensing in Biofilms: A Comprehensive Review

Journal of Chemistry, Volume 2025, Issue 1, 2025.
The formation of biofilms occurs due to a group of bacteria gathering together. The increasing of cell density will stimulate chemical signals for bacteria to communicate through quorum sensing system. Quorum sensing plays a role for competition, virulence, resistance, and pathogenesis. Quorum sensing produces signaling response called as autoinducers.
Salsabila Aqila Putri, Euis Julaeha, Natsuko Kagawa, Dikdik Kurnia, Senthilkumar Nangan   +4 more
wiley   +1 more source

Examination of \u3cem\u3eKlebsiella pneumoniae\u3c/em\u3e 5\u27-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase and 5-Methylthioribose Kinase [PDF]

, 2016
Klebsiella pneumoniae is an opportunistic bacterial pathogen that is emerging as a major global threat as an infectious agent. This organism, along with many other pathogens, possesses a broad suite of antibiotic resistances that can make treatment ...
Stonick, Jason Alan
core   +1 more source

ORENZA: a web resource for studying ORphan ENZyme activities [PDF]

, 2006
BACKGROUND: Despite the current availability of several hundreds of thousands of amino acid sequences, more than 36% of the enzyme activities (EC numbers) defined by the Nomenclature Committee of the International Union of Biochemistry and Molecular ...
A Bairoch, A Bairoch, A Fleischmann, Bernard Labedan, DG Naumoff, DL Wheeler, HM Berman, I Schomburg, M Kanehisa, ML Green, N Hulo, O Lespinet, O Lespinet, Olivier Lespinet, PD Karp   +14 more
core   +4 more sources

Chemoenzymatic Synthesis of Plant‐Derived Kavalactone Natural Products by Dynamic Resolution Using a Biosynthetic O‐Methyltransferase Tailoring Enzyme

ChemCatChem, Volume 16, Issue 23, December 6, 2024.
The O‐methyltransferase JerF was isolated in form of an MBP fusion protein, purified and characterized. Enantioselective O‐methylation of styryl‐dihydropyrandiones by the enzyme was observed. Exploiting this feature, in combination with a spontaneous racemization reaction under enzyme assay conditions, provided a late‐stage dynamic resolution that was ...
Simon Rydzek, Florian Guth, Steffen Friedrich, Jakob Noske, Birte Höcker, Frank Hahn   +5 more
wiley   +1 more source

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells [PDF]

, 2015
SummaryStem cells undergo a shift in metabolic substrate utilization during specification and/or differentiation, a process that has been termed metabolic reprogramming.
Clermont, Daphney, Dell’Orso, Stefania, Derfoul, Assia, Feng, Xuesong, Fulco, Marcella, Gutierrez-Cruz, Gustavo, Juan, Aster, Koulnis, Miroslav, Ryall, James G., Sartorelli, Vittorio, Zare, Hossein   +10 more
core   +1 more source

Cellular senescence mediates retinal ganglion cell survival regulation post‐optic nerve crush injury

Cell Proliferation, Volume 57, Issue 12, December 2024.
This study revealed the activation of cellular senescence in rodent retina post‐optic nerve injury and contribute to retinal ganglion cell survival regulation. Senolytics and TGF‐β receptor inhibitor can be the potential treatment strategies promoting retinal ganglion cell survival after optic nerve injury by targeting cellular senescence.
Yao Yao, Xin Bin, Yanxuan Xu, Shaowan Chen, Si Chen, Xiang‐Ling Yuan, Yingjie Cao, Tsz Kin Ng   +7 more
wiley   +1 more source