Results 11 to 20 of about 2,867 (123)
Emissive Synthetic Cofactors: A Highly Responsive NAD+ Analogue Reveals Biomolecular Recognition Features [PDF]
, 2019 Apart from its vital function as a redox cofactor, nicotinamide adenine dinucleotide (NAD+ ) has emerged as a crucial substrate for NAD+ -consuming enzymes, including poly(ADP-ribosyl)transferase 1 (PARP1) and CD38/CD157.
Feldmann, Jonas, Tor, Yitzhak, Li, Yao
core +1 more source
, 2021 Saporin, a type I ribosome-inactivating protein from soapwort plant, is a potent protein synthesis inhibitor. Catalytically, saporin is a characteristic N-glycosidase, and it depurinates a specific adenine residue from a universally conserved loop of the
Murat Kara, Hafize Akgul, Idris Arslan
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Ureide biogenesis and the enzymes of ammonia assimilation and ureide biosynthesis in nitrogen fixing pigeonpea (Cajanus cajan) nodules [PDF]
, 1984 Allantoic acid production from IMP, XMP, inosine, xanthosine, hypoxanthine, xanthine, uric acid and allantoin was investigated by incubating each of these substrates withCajanus cajan cytosol and bacteroid fractions separately in the presence and absence
Singh, Randhir, Amarjit,
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Regulation of Key Immune-Related Genes in the Heart Following Burn Injury
, 2022 Immune cascade is one of major factors leading to cardiac dysfunction after burn injury. TLRs are a class of pattern-recognition receptors (PRRs) that initiate the innate immune response by sensing conserved molecular patterns for early immune ...
Radhakrishnan, Geetha L. +7 more
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Cytogenomic Integrative Network Analysis of the Critical Region Associated with Wolf-Hirschhorn Syndrome [PDF]
, 2018 Deletions in the 4p16.3 region are associated with Wolf-Hirschhorn syndrome (WHS), a contiguous gene deletion syndrome involving variable size deletions. In this study, we perform a cytogenomic integrative analysis combining classical cytogenetic methods,
Mergener, Rafaella +13 more
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Exploiting Cell-Free Systems: Implementation and Debugging of a System of Biotransformations [PDF]
, 2010 The orchestration of a multitude of enzyme catalysts allows cells to carry out complex and thermodynamically unfavorable chemical conversions. In an effort to recruit these advantages for in vitro biotransformations, we have assembled a 10-step catalytic
Billerbeck, Sonja, +11 more
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, 2021 As a sustainable alternative for the synthesis of biologically active compounds enzymes are contributing to the growing field of green chemistry. A useful modification step is the introduction of a methyl group, which is catalysed by methyltransferases ...
Popadić, Désirée
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Purification, Characterization, and Gene Cloning of Purine Nucleosidase from Ochrobactrum anthropi
, 2001 A bacterium, Ochrobactrum anthropi , produced a large amount of a nucleosidase when cultivated with purine nucleosides. The nucleosidase was purified to homogeneity.
Jun Ogawa +6 more
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Context‐Dependent Chemoselectivity of Aromatic C‐Methyltransferases
ChemBioChem, Volume 27, Issue 8, April 2026.Chemoselectivity is context‐dependent: The SAM‐dependent C‐MTs SfmM2 and NapB5 from streptomycetes catalyze the C‐ and/or O‐dimethylation of aromatic substrates, including l‐tyrosine and flavonoids. C‐methylation activity requires precise substrate recognition and positioning to ensure proximity between the target carbon nucleophile and the methyl ...
Juliane Breiltgens +4 more
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina +10 more
wiley +2 more sources