Results 31 to 40 of about 2,867 (123)

Tumor Microenvironment‐Responsive Nanomedicines for Potentiating Cancer Immunotherapy

Advanced Science, Volume 12, Issue 40, October 27, 2025.
Strategies for TME‐responsive Nanomaterials to Potentiate Cancer Immunotherapy. Abstract Immunotherapy has emerged as a transformative paradigm in oncology, yet its clinical efficacy remains constrained by the immunosuppressive tumor microenvironment and inadequate spatiotemporal control of existing modalities, resulting in suboptimal patient response ...
Qianqian Huang, Fan Tong, Jiantao Chen, Muzaffar Kayumov, Yue Lv, Yajun Shi, Bengui Ye, Huile Gao   +7 more
wiley   +1 more source

The Role of the Intestinal Microbiome in the Pathogenesis and Treatment of Hyperuricemia: A Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review summarizes the characteristics, prevalence, and treatment strategies of hyperuricemia, and subsequently examines its pathogenic mechanisms together with the potential roles and regulatory pathways of the gut microbiota in its alleviation.
Junyu Yang, Jiali Chen, Zhenmin Liu, Yezhi Qu, Xiqing Yue, Bo Yuan, Mohan Li   +6 more
wiley   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2456-2464, September 2025.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Shoot Nitrate Status Regulates Arabidopsis Shoot Growth and Systemic Transcriptional Responses via Shoot Adenosine Phosphate‐Isopentenyltransferase 3

Physiologia Plantarum, Volume 177, Issue 5, September/October 2025.
ABSTRACT Plants systemically regulate growth and gene expression according to their internal nitrate status. Our previous study reported that shoot nitrate accumulation increases shoot expression of adenosine phosphate‐ISOPENTENYLTRANSFERASE 3 (IPT3) and shoot levels of N6‐(Δ2‐isopentenyl) adenine (iP)‐type cytokinins (CKs).
Kota Monden, Takamasa Suzuki, Mikiko Kojima, Yumiko Takebayashi, Daisuke Sugiura, Tsuyoshi Nakagawa, Hitoshi Sakakibara, Takushi Hachiya   +7 more
wiley   +1 more source

Co‐Expression of MHC‐II and ANXA1: Mediators of PD‐1/PD‐L1 Therapy Resistance in Breast Cancer

Cancer Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background Triple‐negative breast cancer (TNBC) presents significant treatment challenges and poor prognosis. While immune checkpoint blockade (ICB) therapy shows promise, patient responses vary widely, highlighting the urgent need for reliable biomarkers to predict efficacy and guide treatment decisions.
Hao Wang, Ji‐Feng Sun, Chen Wang, Zhan‐Sheng Jiang, Zhong‐Sheng Tong   +4 more
wiley   +1 more source

Modeling and Optimization of Microwave Vacuum Drying for Pinelliae Rhizoma: Integrating Drying Kinetics, Artificial Neural Networks, and Quality Preservation

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
The peeled Pinellia ternata (Thunb.) Breit tubers were dried with the microwave vacuum drying oven. Then, its drying characteristics, contents of nucleosides, and surface microstructural alterations of dried samples were determined, respectively. Drying parameters were predicted and optimized using four different mathematical models and artificial ...
Pan Wang, Xiaoping Yang, Xiaopeng Huang, Guojun Ma, Shidong Zhang, Siqi Wang, Ming Wang, Zewen Zhu, Yanrui Xu, ZePeng Zang, Xu Liu   +10 more
wiley   +1 more source

Disruption of mc1r Disturbs Skin Pigmentation in Xenopus tropicalis

Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.
ABSTRACT The melanocortin 1 receptor (MC1R) is well‐established as a pivotal regulator of pigmentation in various species. Despite a wealth of research focused on mammals and fish, the role of Mc1r in amphibians has remained largely unexplored. This study was designed to elucidate the contribution of Mc1r in Xenopus tropicalis.
Lanxin Li, Jixuan Huang, Yonglong Chen, Rensen Ran   +3 more
wiley   +1 more source

In Vitro Psilocybin Synthesis by Co‐Immobilized Enzymes

Chemistry – A European Journal, Volume 31, Issue 29, May 22, 2025.
The drug candidate and psychedelic mushroom product psilocybin was produced by multienzyme‐charged beads in a biocatalytic cell‐free approach. Using immobilized fungal indolethylamine biosynthetic and additional bacterial enzymes, these beads turned over 4‐hydroxy‐l‐tryptophan to psilocybin.
Tim Schäfer, Alexander Sherwood, Thomas Kirkland, Thomas Krüger, Jakob Worbs, Olaf Kniemeyer, Markus Gressler, Dirk Hoffmeister   +7 more
wiley   +1 more source

Concanavalin A-Binding Enzymes of Crotalus scutulatus scutulatus Venom

, 1985
Crotalus scutulatus scutulatus crude venom was separated into two fractions by Concanavalin A Sepharose 4B affinity chromatography. The proteins binding to Con A exhibited phosphomonoesterase (orthophosphoric monoester phosphohydrolase EC 3.1.3.2 ...
Sifford, Dewey H., Johnson, Bob D., Childs, C. K., Hinson, Michael W.   +3 more
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Análise citogenética integrativa da região crítica 4p16.3 associada à síndrome de Wolf-Hirschhorn mecanismos relacionados à rearranjos croossômicos

, 2018
A ocorrência de rearranjos genômicos que afetam um mesmo segmento cromossômico sugerem a presença de mecanismos de recombinação envolvendo regiões cromossômicas críticas suscetíveis a alterações patogênicas. A deleção/duplicação parcial da região crítica
Corrêa, Thiago
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