Results 71 to 80 of about 761,247 (215)

Metabolic control of mitophagy

European Journal of Clinical Investigation, Volume 54, Issue 4, April 2024.
Abstract Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Kroemer, Mahmoud Abdellatif   +6 more
wiley   +1 more source

Highly efficient 5\u27 capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase [PDF]

, 2018
Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription
Basu, Urmimala, Bird, Jeremy G, Ebright, Richard H., Grudzien-Nogalska, Ewa, Kiledjian, Megerditch, Kuster, David, Nickels, Bryce E., Patel, Smita S., Ramachandran, Aparna, Temiakov, Dmitry, Towheed, Atif, Wallace, Douglas C.   +11 more
core   +1 more source

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry [PDF]

, 2018
Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases.
Angelucci, Francesco, Ardini, Matteo, Arner, Elias S. J., Bellelli, Andrea, Boumis, Giovanna, Chen, Qing, Fata, Francesca, Ippoliti, Rodolfo, Jadhav, Ajit, Lea, Wendy A., Lyu, Haining, Miele, Adriana E., Petukhov, Pavel A., Silvestri, Ilaria, Simeonov, Anton, Thatcher, Gregory R. J., Williams, David L.   +16 more
core   +3 more sources

Postoj studentů sociální pedagogiky k homoparentálním rodinám [PDF]

Sociální Pedagogika
The paper is focused on the research of the attitude of the students of the Bachelor's and Master's degree programmes in social pedagogy from the J. E.
Pavel Doulík, Jiří Škoda, Barbora Čechová, Zuzana Procházková   +3 more
doaj   +1 more source

Bud blight (Gemmamyces piceae) in the eastern part of the Krušné hory Mountains

Journal of Forest Science, 2020
A survey was carried out in 2013-2019 on the life cycle of the bud blight Gemmamyces piceae (Borthw.) Casagrande and the trend assessment in the infestation of the Colorado blue spruce Picea pungens Engelm. stands.
Jiří Šefl, Veronika Mottlová, Iva Schořálková   +2 more
doaj   +1 more source

Unusual Enzymatic Hydrolysis of NAD by Solubilized Form of NAD+ Glycohydrolase.

Chemical and Pharmaceutical Bulletin, 2002
Using solubilized form (sNADase) of membrane-bound porcine brain NAD(+) glycohydrolase (pNADase), the NADase-catalyzed hydrolysis and transglycosidation reactions of NAD (1) were examined. Unexpectedly, products in the reactions were found to be nicotinamide (5'-O-diphosphono)-beta-D-ribofuranoside (4) and adenosine (5).
Masanori Hatakeyama, Shuichi Tono-oka
openaire   +3 more sources

Personalized Porous Gelatin Methacryloyl Sustained‐Release Nicotinamide Protects Against Noise‐Induced Hearing Loss

Advanced Science, Volume 11, Issue 12, March 27, 2024.
NAD+ decreases in cochlear after noise trauma, and nicotinamide supplementation boosts NAD+ and prevents neuroexcitatory in cochlear by round window administration. Personalized porous gelatin methacryloyl (PGMA) achieves long term drug release in cochlear, and nicotinamide encapsulated PGMA enhances mitochondria and synapse function, and protects ...
Baoyi Feng, Tingting Dong, Xinyu Song, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Liu, Wenjie Zhang, Xueling Wang, Yong Tao, Hao Wu   +10 more
wiley   +1 more source

A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation. [PDF]

, 2019
Nicotinamide adenine dinucleotide (NAD+)-dependent ADP-ribosylation plays important roles in physiology and pathophysiology. It has been challenging to study this key type of enzymatic post-translational modification in particular for protein poly-ADP ...
Chen, Jingwen, Cheng, Qinqin, Dai, Zhefu, Evdokimov, Nikolai M, Lam, Albert T, Louie, Stan G, Lu, Yanran, Pei, Hua, Zhang, Xiao-Nan, Zhang, Yong   +9 more
core   +1 more source

Biodistribution and toxicity assessment of methoxyphenyl phosphonium carbosilane dendrimers in 2D and 3D cell cultures of human cancer cells and zebrafish embryos

Scientific Reports, 2023
The consideration of human and environmental exposure to dendrimers, including cytotoxicity, acute toxicity, and cell and tissue accumulation, is essential due to their significant potential for various biomedical applications.
Zuzana Žmudová, Zuzana Šanderová, Michaela Liegertová, Stanislav Vinopal, Regina Herma, Luděk Sušický, Monika Müllerová, Tomáš Strašák, Jan Malý   +8 more
doaj   +1 more source

Aerial Bombing Crater Identification: Exploitation of Precise Digital Terrain Models

ISPRS International Journal of Geo-Information, 2020
Places of past conflicts and persistent objects that reflect such events often attract the attention of archaeological prospection which facilitates the construction of conflict narratives. Field prospection as a precise method for localization of aerial
Martin Dolejš, Jan Pacina, Martin Veselý, Dominik Brétt   +3 more
doaj   +1 more source