Results 71 to 80 of about 299,285 (291)

Effect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair‐Deficient 3xTg/POLβ+/− Alzheimer Disease Mouse Model

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Alzheimer disease causes neurodegeneration of the hippocampus. It impedes brain glucose metabolism and impairs mitochondrial energy along electron transport chain (ETC). Will a ketone‐based diet with nicotinamide riboside restore hippocampal energy in an Alzheimer mouse model?
Robert Pawlosky, Tyler G. Demarest, M. Todd King, Darlene Estrada, Richard L. Veech, Vilhelm A. Bohr   +5 more
wiley   +1 more source

PGC‐1a integrates a metabolism and growth network linked to caloric restriction

Aging Cell, Volume 18, Issue 5, October 2019., 2019
We show that activation of mitochondria via PGC‐1a in cells impinges on diverse functions including chromatin remodeling and RNA processing. We suggest that this PGC‐1a‐directed network is implicated in the mechanisms of delayed aging by caloric restriction.
Karl N. Miller, Josef P. Clark, Stephen A. Martin, Porsha R. Howell, Maggie S. Burhans, Spencer A. Haws, Nathan B. Johnson, Timothy W Rhoads, Derek M. Pavelec, Kevin W. Eliceiri, Avtar S. Roopra, James M. Ntambi, John M. Denu, Brian W. Parks, Rozalyn M. Anderson   +14 more
wiley   +1 more source

Bioprospecting of a Novel Plant Growth-Promoting Bacterium Bacillus altitudinis KP-14 for Enhancing Miscanthus × giganteus Growth in Metals Contaminated Soil

Biology, 2020
Use of plant growth-promoting bacteria (PGPB) for cultivation of the biofuel crop Miscanthus × giganteus (Mxg) in post-military and post-mining sites is a promising approach for the bioremediation of soils contaminated by metals.
Kumar Pranaw, Valentina Pidlisnyuk, Josef Trögl, Hana Malinská   +3 more
doaj   +1 more source

Dual treatment with kynurenine pathway inhibitors and NAD+ precursors synergistically extends life span in Drosophila

Aging Cell, Volume 23, Issue 4, April 2024.
Our study explores the impact of kynurenine pathway (KP) modulation and NAD+ supplementation on aging Drosophila. We found that KP inhibition combined with NAD+ precursors significantly enhances physical performance and extends life span. These findings suggest that targeted interventions in KP and NAD+ metabolism can synergistically improve health ...
Mariann M. Gabrawy, Reyhan Westbrook, Austin King, Nick Khosravian, Neeraj Ochaney, Tagide DeCarvalho, Qinchuan Wang, Yuqiong Yu, Qiao Huang, Adam Said, Michael Abadir, Cissy Zhang, Pratik Khare, Jennifer E. Fairman, Anne Le, Ginger L. Milne, Fernando J. Vonhoff, Jeremy D. Walston, Peter M. Abadir   +18 more
wiley   +1 more source

SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis

Aging Cell, Volume 17, Issue 6, December 2018., 2018
Abstract SIRT1 is an NAD+‐dependent deacetylase that functions in a variety of cells and tissues to mitigate age‐associated diseases. However, it remains unknown if SIRT1 also acts to prevent pathological changes that accrue in motor neurons during aging and amyotrophic lateral sclerosis (ALS).
Adrianna Z. Herskovits, Tegan A. Hunter, Nicholas Maxwell, Katherine Pereira, Charles A. Whittaker, Gregorio Valdez, Leonard P. Guarente   +6 more
wiley   +1 more source

Bud blight (Gemmamyces piceae) in the eastern part of the Krušné hory Mountains

Journal of Forest Science, 2020
A survey was carried out in 2013-2019 on the life cycle of the bud blight Gemmamyces piceae (Borthw.) Casagrande and the trend assessment in the infestation of the Colorado blue spruce Picea pungens Engelm. stands.
Jiří Šefl, Veronika Mottlová, Iva Schořálková   +2 more
doaj   +1 more source

NADS: Neural Architecture Distribution Search for Uncertainty Awareness [PDF]

arXiv, 2020
Machine learning (ML) systems often encounter Out-of-Distribution (OoD) errors when dealing with testing data coming from a distribution different from training data. It becomes important for ML systems in critical applications to accurately quantify its predictive uncertainty and screen out these anomalous inputs.
arxiv  

Metabolic control of mitophagy

European Journal of Clinical Investigation, Volume 54, Issue 4, April 2024.
Abstract Mitochondrial dysfunction is a major hallmark of ageing and related chronic disorders. Controlled removal of damaged mitochondria by the autophagic machinery, a process known as mitophagy, is vital for mitochondrial homeostasis and cell survival.
Andreas Zimmermann, Frank Madeo, Abhinav Diwan, Junichi Sadoshima, Simon Sedej, Guido Kroemer, Mahmoud Abdellatif   +6 more
wiley   +1 more source

Postoj studentů sociální pedagogiky k homoparentálním rodinám [PDF]

Sociální Pedagogika
The paper is focused on the research of the attitude of the students of the Bachelor's and Master's degree programmes in social pedagogy from the J. E.
Pavel Doulík, Jiří Škoda, Barbora Čechová, Zuzana Procházková   +3 more
doaj   +1 more source

Personalized Porous Gelatin Methacryloyl Sustained‐Release Nicotinamide Protects Against Noise‐Induced Hearing Loss

Advanced Science, Volume 11, Issue 12, March 27, 2024.
NAD+ decreases in cochlear after noise trauma, and nicotinamide supplementation boosts NAD+ and prevents neuroexcitatory in cochlear by round window administration. Personalized porous gelatin methacryloyl (PGMA) achieves long term drug release in cochlear, and nicotinamide encapsulated PGMA enhances mitochondria and synapse function, and protects ...
Baoyi Feng, Tingting Dong, Xinyu Song, Xiaofei Zheng, Chenxi Jin, Zhenzhe Cheng, Yiqing Liu, Wenjie Zhang, Xueling Wang, Yong Tao, Hao Wu   +10 more
wiley   +1 more source