Results 211 to 220 of about 11,490,346 (250)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

NAD⁺ Metabolic Reprogramming Drives CD8⁺ T Cells Senescence and Exacerbates Ulcerative Colitis. [PDF]

Aging Cell
Ye M, Zhou Q, Kong M, Zhao S, Lin L, Chen L, Yu J, Luo F, Liu J, Zhang J.   +9 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Dynamics of blood NAD and glutathione in health, disease, aging, and under NAD⁺-booster treatment. [PDF]

Redox Biol
Euro L, Haimilahti K, Jansson S, Forsström S, Buzkova J, Suomalainen A.   +5 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Beyond NAD Depletion: SARM1-Induced ATP Collapse Involves Direct ATP Degradation and Mitochondrial Dysfunction and Is Pharmacologically Reversible. [PDF]

Biology (Basel)
Chen Z, Zhao ZY, Zhang ZM, Zhao R, Shen L, Lee HC, Fang L, Zhao YJ.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Pyrroloquinoline Quinone and NAD⁺ Metabolism in Glaucoma: A Molecular Rationale for Combined Neuroprotection. [PDF]

Pharmaceuticals (Basel)
Medoro A, Davinelli S, Mazzotta CG, Agnifili L, Scapagnini G.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Nicotinamide Riboside Attenuates Cisplatin-Induced Hepatorenal Toxicity Through Restoration of NAD⁺ Homeostasis and Nrf2/NQO1-Dependent Antioxidant Signaling. [PDF]

Cells
Albahadly WKY, Rasool MI, Al-Saedi HFS, Al-Kareem ZA, Hasan SA, Sahib MA, ALtrufi MH.   +6 more
europepmc   +1 more source