Results 51 to 60 of about 1,176,786 (313)

Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mTOR-Sirtuin signaling

Journal of Ginseng Research, 2020
Background: The replicative senescence of human dermal fibroblasts (HDFs) is accompanied by growth arrest. In our previous study, the treatment of senescent HDFs with Rg3(S) lowered the intrinsic reactive oxygen species (ROS) levels and reversed cellular
Kyeong-Eun Yang, Hyun-Jin Jang, In-Hu Hwang, Eun Mi Hong, Min-Goo Lee, Soon Lee, Ik-Soon Jang, Jong-Soon Choi   +7 more
doaj   +1 more source

Evidence for two NAD kinases in Salmonella typhimurium [PDF]

Journal of Bacteriology, 1994
The electron-carrying cofactor NADP is formed by phosphorylation of NAD. A strategy for the isolation of NAD kinase mutants revealed two classes of temperature-sensitive mutations, nadF and nadG, mapping at min 13 and 72 of the Salmonella chromosome.
W, Cheng, J R, Roth
openaire   +2 more sources

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]

, 2008
We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Vollmar, Angelika M., Zahler, Stefan, Fürst, Robert   +2 more
core   +1 more source

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype

Frontiers in Endocrinology, 2022
Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Chisaka Kuehnemann, Chisaka Kuehnemann, Kang-Quan Hu, Kayla Butera, Sandip K. Patel, Joanna Bons, Birgit Schilling, Cristina Aguayo-Mazzucato, Christopher D. Wiley   +8 more
doaj   +1 more source

Cisplatin-Induced Kidney Toxicity: Potential Roles of Major NAD⁺-Dependent Enzymes and Plant-Derived Natural Products

Biomolecules, 2022
Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major
Amany Iskander, Liang-Jun Yan
doaj   +1 more source

Nitric oxide-induced activation of the AMP-activated protein kinase alpha2 subunit attenuates IKappaB kinase activity and inflammatory responses in endothelial cells

, 2011
Background: In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood.
Timo Frömel, Ingrid Fleming, Beß, Elke, Fißlthaler, Beate, Elke Bess, Fleming, Ingrid, Frömel Timo, Bess Elke, Fisslthaler Beate, Beate Fisslthaler, Frömel, Timo, Fleming Ingrid   +11 more
core   +1 more source

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells

Molecular Metabolism, 2017
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Rachel S. Fletcher, Joanna Ratajczak, Craig L. Doig, Lucy A. Oakey, Rebecca Callingham, Gabriella Da Silva Xavier, Antje Garten, Yasir S. Elhassan, Philip Redpath, Marie E. Migaud, Andrew Philp, Charles Brenner, Carles Canto, Gareth G. Lavery   +13 more
doaj   +1 more source

Fluorometric procedures for measuring triglyceride concentrations in small amounts of tissue and plasma.

Journal of Lipid Research, 1988
It has been previously shown that triglycerides can be specifically hydrolyzed by lipase from Rhizopus arrhizus in the presence of hog liver esterase and sodium dodecyl sulfate.
P M Nemeth, O E Hitchins, L Solanki, T G Cole   +3 more
doaj   +1 more source

NAD Kinase by Quinolinic Acid

, 2003
NADP is essential for biosynthetic pathways, energy, and signal transduction. In living organisms, NADP biosynthesis proceeds through the phosphorylation of NAD with a reaction catalyzed by NAD kinase.
Menico Rizzi, Silvia Garavaglia, Alessandro Galizzi, GALIZZI, ALESSANDRO, GARAVAGLIA, Silvia, Galizzi A, RIZZI, Menico, RIZZI M.   +7 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source