Results 31 to 40 of about 739,530 (281)
Cryo-EM structure and regulation of human NAD kinase. [PDF]
Sci AdvReduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress. To fulfill their heightened anabolic and reductive power demands, cancer cells must boost their NADPH production.
Praharaj PP +18 more
europepmc +4 more sources
Journal of Diabetes Investigation, 2020 One of the biochemical abnormalities found in diabetic tissues is a decrease in the cytosolic oxidized to reduced forms of the nicotinamide adenine dinucleotide ratio (NAD+/NADH also known as pseudohypoxia) caused by oxidation of excessive substrates ...
Lan Fan, Jose M. Cacicedo, Yasuo Ido
doaj +1 more source
The NAD Kinases of Saccharomyces cerevisiae [PDF]
European Journal of Biochemistry, 1970 Subcellular fractions of a strain of Saccharomyces cerevisiae have been prepared by enzymic digestion of the cell walls, osmotic lysis of the protoplasts and sorbitol density gradient centrifugation of the lysate. The mitochondrial fraction has both NAD‐ and NADH‐phosphorylating enzymes, whilst the cytoplasm contains a single NAD‐specific kinase. These
openaire +2 more sources
Combinatorial strategy using protein kinase inhibitors and a cytotoxic compound for highly resistant glioblastoma cells : "in vitro studies" [PDF]
, 2007 Glioblastoma multiforme (GBM) is the most frequent and the most aggesssive malignant neoplasm of the human central nervous system (CNS), with a median survival of less than one year. These neoplasms are radio- and chemo-resistant, and are highly invasive,
Failly, Mike
core +1 more source
The effector AvrRxo1 phosphorylates NAD in planta. [PDF]
PLoS Pathogens, 2017 Gram-negative bacterial pathogens of plants and animals employ type III secreted effectors to suppress innate immunity. Most characterized effectors work through modification of host proteins or transcriptional regulators, although a few are known to ...
Teja Shidore +7 more
doaj +1 more source
Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D [PDF]
, 2007 Phosphoinoisitide dependent kinase l (PDK1) is proposed to phosphorylate a key threonine residue within the catalytic domain of the protein kinase C (PKC) superfamily that controls the stability and catalytic competence of these kinases.
Kelly, April P. +3 more
core +1 more source
Nutraceutical activation of Sirt1: a review
Open Heart, 2022 The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as an ‘anti-aging’ enzyme. Practical measures which might
James J DiNicolantonio +2 more
doaj +1 more source
Over-expression of NAD kinase in Corynebacterium crenatum and its Impact on L-Arginine Biosynthesis [PDF]
, 2013 Purpose: To improve the biosynthesis of L-arginine by overexpressing homologous NAD kinase (ppnk) in Corynebacterium crenatum SYPA5-5 and to study its impact in presence of high (HOS) and low oxygen supply (LOS).
Xu, Zhenghong +4 more
core +4 more sources
Evidence for two NAD kinases in Salmonella typhimurium [PDF]
Journal of Bacteriology, 1994 The electron-carrying cofactor NADP is formed by phosphorylation of NAD. A strategy for the isolation of NAD kinase mutants revealed two classes of temperature-sensitive mutations, nadF and nadG, mapping at min 13 and 72 of the Salmonella chromosome.
W, Cheng, J R, Roth
openaire +2 more sources
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation [PDF]
, 2014 Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis.
Schmid, Ralf +8 more
core +3 more sources