Results 11 to 20 of about 1,176,786 (313)

MNADK, a novel liver-enriched mitochondrion-localized NAD kinase

Biology Open, 2013
Summary NADP+ and its reducing equivalent NADPH are essential for counteracting oxidative damage. Mitochondria are the major source of oxidative stress, since the majority of superoxide is generated from the mitochondrial respiratory chain. Because NADP+
Ren Zhang
doaj   +3 more sources

Cryo-EM structure and regulation of human NAD kinase. [PDF]

Sci Adv
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress. To fulfill their heightened anabolic and reductive power demands, cancer cells must boost their NADPH production.
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G.   +18 more
europepmc   +4 more sources

(-)-Epigallocatechin Gallate is a Noncompetitive Inhibitor of NAD Kinase. [PDF]

ACS Med Chem Lett, 2022
Nicotinamide adenine dinucleotide kinase (NADK) controls the intracellular NADPH content and provides reducing power for the synthesis of macromolecules and anti-ROS. Moreover, NADK is considered to be a synthetic lethal gene for KRAS mutations. To discover NADK-targeted probes, a high-throughput screening assay was established and optimized with a Z ...
Liu T, Shi W, Ding Y, Wu Q, Zhang B, Zhang N, Wang M, Du D, Zhang H, Han B, Guo D, Zheng J, Li Q, Luo C.   +13 more
europepmc   +3 more sources

Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. [PDF]

Gastroenterology, 2018
Background & Aims The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (NADK2, also called MNADK) catalyzes phosphorylation of NAD to yield NADP.
Zhang K, Kim H, Fu Z, Qiu Y, Yang Z, Wang J, Zhang D, Tong X, Yin L, Li J, Wu J, Qi NR, Houten SM, Zhang R.   +13 more
europepmc   +2 more sources

Physiological Significance of NAD Kinases in Cyanobacteria

Frontiers in Plant Science, 2019
Unicellular cyanobacteria are thought to be the evolutionary ancestors of plant chloroplasts and are widely used both for chemical production and as model organisms in studies of photosynthesis. Although most research focused on increasing reducing power
Yuuma Ishikawa, Maki Kawai-Yamada
doaj   +3 more sources

Identification and characterization of a human mitochondrial NAD kinase [PDF]

Nature Communications, 2012
NAD kinase is the sole NADP(+) biosynthetic enzyme. Despite the great significance of NADP(+), to date no mitochondrial NAD kinase has been identified in human, and the source of human mitochondrial NADP(+) remains elusive. Here we present evidence demonstrating that a human protein of unknown function, C5orf33, is a human mitochondrial NAD kinase ...
Ohashi, Kazuto, Kawai, Shigeyuki, Murata, Kousaku   +2 more
openaire   +4 more sources

NAD Kinase in Higher Plants. [PDF]

Plant Physiology, 1966
NAD kinase was exclusively found in the soluble portion of the cell components. The enzyme was purified about 100-fold from sucrose extracts of spinach leaves.Plant NAD kinase catalyzes formation of NADP from NAD, ATP, and Mg(++), but scarcely any formation of NADPH from NADH. NADH was a very potent competitive inhibitor of NAD phosphorylation by plant
Y. Yamamoto
semanticscholar   +3 more sources

The NAD kinase Slr0400 functions as a growth repressor in Synechocystis sp. PCC 6803.

Plant and Cell Physiology, 2021
NADP+, the phosphorylated form of nicotinamide adenine dinucleotide (NAD), plays an essential role in many cellular processes. NAD kinase (NADK), which is conserved in all living organisms, catalyzes the phosphorylation of NAD+ to NADP+.
Yuuma Ishikawa, C. Cassan, Aikeranmu Kadeer, Koki Yuasa, Nozomu J. Sato, K. Sonoike, Y. Kaneko, A. Miyagi, Hiroko Takahashi, T. Ishikawa, M. Yamaguchi, Y. Nishiyama, Y. Hihara, Y. Gibon, M. Kawai‐Yamada   +14 more
semanticscholar   +2 more sources

Identification of the Arabidopsis Calmodulin-Dependent NAD+ Kinase That Sustains the Elicitor-Induced Oxidative Burst1 [PDF]

Plant Physiology, 2019
A long-sought calmodulin- and Ca2+-dependent NAD kinase that is conserved in the plant lineage is the missing link between Ca2+ signaling, metabolism, and the oxidative burst. NADP(H) is an essential cofactor of multiple metabolic processes in all living
Elisa Dell’Aglio, C. Giustini, Alexandra Kraut, Y. Couté, Alex Costa, Guillaume Decros, Y. Gibon, C. Mazars, M. Matringe, G. Finazzi, G. Curien   +10 more
semanticscholar   +2 more sources

Kinetic studies of pigeon liver NAD kinase. [PDF]

European Journal of Biochemistry, 1968
A procedure for the purification of NAD kinase from pigeon liver acetone powder is described. Although not homogeneous, the preparation is largely free of enzymes which interfere with the assay of NAD kinase. The kinetics with magnesium as the activating ion are described: from Interrelationships between the kinetic coefficients, the modes of ...
D. Apps
semanticscholar   +3 more sources