Mitochondrial NAD kinase Pos5 is required for CoQ biosynthesis in yeasts [PDF]
PLoS ONECoenzyme Q (CoQ) is an essential component of the electron transport chain, and ten genes involved in CoQ biosynthesis have been identified in Schizosaccharomyces pombe. To gain further insight into CoQ biosynthesis, we screened the Bioneer gene-deletion
Shogo Nishihara +4 more
doaj +3 more sources
Over-expression of NAD kinase in Corynebacterium crenatum and its Impact on L-Arginine Biosynthesis
, 2013 Purpose : To improve the biosynthesis of L-arginine by overexpressing homologous NAD kinase (ppnk) in Corynebacterium crenatum SYPA5-5 and to study its impact in presence of high (HOS) and low oxygen supply (LOS).
M. M. Rahman +4 more
semanticscholar +5 more sources
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
PLoS Biology, 2007 The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and ...
Wolfram Tempel +10 more
doaj +2 more sources
Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant. [PDF]
Am J Med Genet A, 2018 Pomerantz DJ +19 more
europepmc +2 more sources
Altered metabolism of chloroplastic NAD kinase-overexpressing Arabidopsis in response to magnesium sulfate supplementation [PDF]
Plant Signaling and Behavior, 2021 Maki Kawai-Yamada +2 more
exaly +2 more sources
Collateral lethality of NAD kinase in 1p36 deleted tumors drives vulnerability to NAD kinase 2 depletion. [PDF]
BBA AdvSuyama-Banjo S +5 more
europepmc +2 more sources
NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis.
Cell Reports, 2021 Lipid storage in fat tissue is important for energy homeostasis and cellular functions. Through RNAi screening in Drosophila fat body, we found that knockdown of a Drosophila NAD kinase (NADK), which phosphorylates NAD to synthesize NADP de novo, causes ...
Mengyao Xu +7 more
semanticscholar +1 more source
Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants
Plant Signaling & Behavior, 2023 Arabidopsis NADK2 (NAD kinase 2) is a chloroplast-localized enzyme involved in NADP+ synthesis, which acts as the final electron acceptor in the photosynthetic electron transfer chain.
chaomurilege +5 more
doaj +1 more source
Frontiers in Immunology, 2022 Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immune function and
Claudia C. S. Chini +17 more
doaj +1 more source
Ameliorating effect of 6-week swimming exercise on mice with experimental autoimmune encephalomyelitis (EAE) by reducing fetuin-A and increasing AMPK & NAD⁺ levels in liver tissue [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Multiple sclerosis (MS) is a chronic inflammatory disease affecting sensory and motor function in the central nervous system. Physical activities in the prevention and treatment of such conditions have shown promising results.
Maryam Nazari +3 more
doaj +1 more source