Mitochondrial NAD kinase in health and disease [PDF]
Redox Biology, 2023 Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron carrier, plays crucial roles in numerous biological functions, including cellular metabolism and antioxidation.
Ren Zhang, Kezhong Zhang
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Molecular properties and regulation of NAD+ kinase (NADK) [PDF]
Redox Biology, 2023 Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria ...
Shin-ichi Oka +3 more
doaj +5 more sources
Measurement of Chloroplastic NAD Kinase Activity and Whole Tissue NAD Kinase Assay [PDF]
Bio-Protocol, 2020 Nicotinamide adenine dinucleotide phosphate (NADP) synthesis requires nicotinamide adenine dinucleotide (NAD) kinase activity, substrate NAD and ATP.
Yuma Ishikawa +2 more
doaj +6 more sources
Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis [PDF]
mBio, 2023 Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative ...
Ritu Sharma +11 more
doaj +5 more sources
New Chemical Probe Targeting Bacterial NAD Kinase [PDF]
Molecules, 2020 Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide phosphate (NADP) levels in many metabolic pathways.
David A. Clément +8 more
doaj +8 more sources
The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand. [PDF]
Mol Metab, 2022 Objective The mitochondrial nicotinamide adenine dinucleotide (NAD) kinase (MNADK) mediates de novo mitochondrial NADP biosynthesis by catalyzing the phosphorylation of NAD to yield NADP.
Kim H +11 more
europepmc +2 more sources
Polyphosphate-dependent nicotinamide adenine dinucleotide (NAD) kinase: A novel missing link in human mitochondria. [PDF]
Proc Jpn Acad Ser B Phys Biol Sci, 2021 Polyphosphate [poly(P)] is described as a homopolymer of inorganic phosphates. Nicotinamide adenine dinucleotide kinase (NAD kinase) catalyzes the phosphorylation of NAD+ to NADP+ in the presence of ATP (ATP-NAD kinase).
Murata K.
europepmc +2 more sources
The NAD kinase OsNADK1 affects the intracellular redox balance and enhances the tolerance of rice to drought. [PDF]
BMC Plant Biol, 2020 NAD kinases (NADKs) are the only known enzymes that directly phosphorylate NAD(H) to generate NADP(H) in different subcellular compartments. They participate in multiple life activities, such as modulating the NADP/NAD ratio, maintaining the ...
Wang X +8 more
europepmc +2 more sources
NAD+ Kinase as a Therapeutic Target in Cancer [PDF]
Clinical Cancer Research, 2016 Abstract NAD+ kinase (NADK) catalyzes the phosphorylation of nicotinamide adenine dinucleotide (NAD+) to nicotinamide adenine dinucleotide phosphate (NADP+) using ATP as the phosphate donor. NADP+ is then reduced to NADPH by dehydrogenases, in particular glucose-6-phosphate dehydrogenase and the malic enzymes.
Philip M. Tedeschi +5 more
semanticscholar +3 more sources
Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. [PDF]
Science, 2019 Akt produces reducing power The protein kinase Akt provides a link from growth factors to the production of metabolic reducing power within the cell. Hoxhaj et al. discovered that Akt directly phosphorylates nicotinamide adenine dinucleotide kinase (NADK)
Hoxhaj G +9 more
europepmc +2 more sources