New Chemical Probe Targeting Bacterial NAD Kinase [PDF]
Molecules, 2020 Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide phosphate (NADP) levels in many metabolic pathways.
David A. Clément +8 more
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Mitochondrial NAD kinase in health and disease [PDF]
Redox Biology, 2023 Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron carrier, plays crucial roles in numerous biological functions, including cellular metabolism and antioxidation.
Ren Zhang, Kezhong Zhang
doaj +4 more sources
Measurement of Chloroplastic NAD Kinase Activity and Whole Tissue NAD Kinase Assay [PDF]
Bio-Protocol, 2020 Nicotinamide adenine dinucleotide phosphate (NADP) synthesis requires nicotinamide adenine dinucleotide (NAD) kinase activity, substrate NAD and ATP.
Yuma Ishikawa +2 more
doaj +5 more sources
Molecular properties and regulation of NAD+ kinase (NADK) [PDF]
Redox Biology, 2023 Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and the NADP(H)-producing mechanism are evolutionarily conserved among archaea, bacteria ...
Shin-ichi Oka +3 more
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Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis [PDF]
mBio, 2023 Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions and have emerged as therapeutic targets in cancer, metabolic disorders, neurodegenerative ...
Ritu Sharma +11 more
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Mitochondrial NAD kinase Pos5 is required for CoQ biosynthesis in yeasts [PDF]
PLoS ONECoenzyme Q (CoQ) is an essential component of the electron transport chain, and ten genes involved in CoQ biosynthesis have been identified in Schizosaccharomyces pombe. To gain further insight into CoQ biosynthesis, we screened the Bioneer gene-deletion
Shogo Nishihara +4 more
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Metabolic changes associated with dark-induced leaf senescence in Arabidopsis nadk2 mutants
Plant Signaling & Behavior, 2023 Arabidopsis NADK2 (NAD kinase 2) is a chloroplast-localized enzyme involved in NADP+ synthesis, which acts as the final electron acceptor in the photosynthetic electron transfer chain.
chaomurilege +5 more
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Frontiers in Immunology, 2022 Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immune function and
Claudia C. S. Chini +17 more
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Ameliorating effect of 6-week swimming exercise on mice with experimental autoimmune encephalomyelitis (EAE) by reducing fetuin-A and increasing AMPK & NAD⁺ levels in liver tissue [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Multiple sclerosis (MS) is a chronic inflammatory disease affecting sensory and motor function in the central nervous system. Physical activities in the prevention and treatment of such conditions have shown promising results.
Maryam Nazari +3 more
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miR-146a impedes the anti-aging effect of AMPK via NAMPT suppression and NAD+/SIRT inactivation
Signal Transduction and Targeted Therapy, 2022 Nicotinamide adenine dinucleotide (NAD+) is indispensable for the anti-aging activity of the sirtuin (SIRT) family enzymes. AMP-activated protein kinase (AMPK) upregulates NAD+ synthesis and SIRT activity in a nicotinamide phosphoribosyltransferase ...
Hui Gong +15 more
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