A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8
Brain Pathology, EarlyView.We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren +5 more
wiley +1 more source
Scrutinizing a Lactococcus lactis mutant with enhanced capacity for extracellular electron transfer reveals a unique role for a novel type-II NADH dehydrogenase. [PDF]
Appl Environ MicrobiolGu L +4 more
europepmc +1 more source
British Journal of Pharmacology, EarlyView.As a metabolically versatile organ, the heart is capable of generating energy from a wide range of substrates. Although fatty acid and glucose metabolism in the heart have been extensively studied, the contribution of amino acid metabolism to cardiac physiology and disease is gaining increasing attention.
Tayyiba Azam +6 more
wiley +1 more source
Cell Proliferation, EarlyView.The lichen‐derived metabolite methyl 4‐O‐demethylbarbatate (Me‐4‐O‐DBA) suppresses glioma stemness, motility, and metabolic plasticity through inhibition of HIF‐1α signaling and synergistically enhances temozolomide activity, highlighting a potential strategy to target stemness‐driven therapeutic resistance in glioma.
Rui Zhou +8 more
wiley +1 more source
Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting <i>Mycobacterium tuberculosis</i> type II NADH dehydrogenase. [PDF]
RSC Med ChemSaha P, Sau S, Kalia NP, Sharma DK.
europepmc +1 more source
The N-terminal domains of the paralogous HycE and NuoCD govern assembly of the respective formate hydrogenlyase and NADH dehydrogenase complexes. [PDF]
FEBS Open Bio, 2020 Skorupa P +5 more
europepmc +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
The FEBS Journal, EarlyView.Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
A chemo‐enzymatic colorimetric cascade for detecting ethylene glycol contamination
The FEBS Journal, EarlyView.A chemo‐enzymatic cascade is developed for ethylene glycol (EG) detection. EG is oxidized by GoADH with C1‐mediated cofactor recycling to produce glycolaldehyde (GAL). GAL subsequently reacts with purpald to generate a detectable purple chromophore.
Tawatchai Singphongam +6 more
wiley +1 more source
Common pathways and outliers in glucose catabolism across Trypanosomatidae
The FEBS Journal, EarlyView.Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes +5 more
wiley +1 more source
Shewanella oneidensis NADH dehydrogenase mutants exhibit an amino acid synthesis defect. [PDF]
Front Energy Res, 2019 Duhl KL, TerAvest MA.
europepmc +1 more source