Results 11 to 20 of about 143,400 (355)

Nanomechanical Study of Enzyme: Coenzyme Complexes: Bipartite Sites in Plastidic Ferredoxin-NADP⁺ Reductase for the Interaction with NADP⁺

Antioxidants, 2022
Plastidic ferredoxin-NADP+ reductase (FNR) transfers two electrons from two ferredoxin or flavodoxin molecules to NADP+, generating NADPH. The forces holding the Anabaena FNR:NADP+ complex were analyzed by dynamic force spectroscopy, using WT FNR and ...
Sandra Pérez-Domínguez, Silvia Caballero-Mancebo, Carlos Marcuello, Marta Martínez-Júlvez, Milagros Medina, Anabel Lostao   +5 more
doaj   +2 more sources

Inter-Organelle NAD Metabolism Underpinning Light Responsive NADP Dynamics in Plants

Frontiers in Plant Science, 2019
Upon illumination, photosystem I in chloroplasts catalyzes light-driven electron transport from plastocyanin to ferredoxin, followed by the reduction of NADP+ to NADPH by ferredoxin:NADP+ reductase for CO2 fixation.
Shin-nosuke Hashida, Maki Kawai-Yamada
doaj   +2 more sources

A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes

Nature Communications
The NADPH/NADP+ redox couple is central to metabolism and redox signalling. NADP redox state is differentially regulated by distinct enzymatic machineries at the subcellular compartment level.
Marie Scherschel, Jan-Ole Niemeier, Lianne J. H. C. Jacobs, Markus D. A. Hoffmann, Anika Diederich, Christopher Bell, Pascal Höhne, Sonja Raetz, Johanna B. Kroll, Janina Steinbeck, Sophie Lichtenauer, Jan Multhoff, Jannik Zimmermann, Tanmay Sadhanasatish, R. Alexander Rothemann, Carsten Grashoff, Joris Messens, Emmanuel Ampofo, Matthias W. Laschke, Jan Riemer, Leticia Prates Roma, Markus Schwarzländer, Bruce Morgan   +22 more
doaj   +2 more sources

Auxin is involved in arbuscular mycorrhizal fungi-promoted tomato growth and NADP-malic enzymes expression in continuous cropping substrates

BMC Plant Biology, 2021
Background Despite significant limitations of growth medium reuse, a large amount of organic substrate is reused in soilless cultivation of horticultural crops in China. Arbuscular mycorrhizal fungi (AMF) can promote nutrient absorption and improve plant
Yu Wang, Wenze Zhang, Weikang Liu, Golam Jalal Ahammed, Wenxu Wen, Shirong Guo, Sheng Shu, Jin Sun   +7 more
doaj   +2 more sources

NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression

Nature Communications, 2019
Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an ...
Chunjing Bian, Chao Zhang, Tao Luo, Aditi Vyas, Shih-Hsun Chen, Chao Liu, Muzaffer Ahmad Kassab, Ying Yang, Mei Kong, Xiaochun Yu   +9 more
doaj   +2 more sources

Mitochondrial NADP(H) generation is essential for proline biosynthesis

Science, 2021
Providing for protein synthesis Compartmentalization of metabolic processes into organelles can have important consequences. Zhu et al. examined the role of the coenzyme nicotinamide adenine dinucleotide phosphate (NADP+) and its reduced form (NADPH) in ...
Jiajun Zhu, Simon Schwörer, Mirela Berisa, Yeon Ju Kyung, K. W. Ryu, Junmei Yi, Xuejun Jiang, J. Cross, C. Thompson   +8 more
semanticscholar   +1 more source

Mitochondrial NADP+ is essential for proline biosynthesis during cell growth

Nature Metabolism, 2021
Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress.
D. H. Tran, R. Kesavan, Halie Rion, Mona H Soflaee, Ashley Solmonson, Divya Bezwada, Hieu S. Vu, Feng Cai, J. Phillips, R. Deberardinis, G. Hoxhaj   +10 more
semanticscholar   +1 more source

G6PD-mediated increase in de novo NADP+ biosynthesis promotes antioxidant defense and tumor metastasis

Science Advances, 2022
Metastasizing cancer cells are able to withstand high levels of oxidative stress through mechanisms that are poorly understood. Here, we show that under various oxidative stress conditions, pancreatic cancer cells markedly expand NADPH and NADP+ pools ...
Yang Zhang, Yi Xu, Wenyun Lu, Jinyang Li, Sixiang Yu, E. Brown, B. Stanger, J. Rabinowitz, Xiaolu Yang   +8 more
semanticscholar   +1 more source

Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH and plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such as hemolytic anemia.
Xuepeng Wei, Kathryn Kixmoeller, Elana E Baltrusaitis, Xiaolu Yang, R. Marmorstein   +4 more
semanticscholar   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I., Engel, P.C., Llinas, M., Muller, S., Olszewski, K., Patzewitz, E.-M., Perner, J., Storm, J.   +7 more
core   +4 more sources