Results 191 to 200 of about 72,905 (323)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, Volume 19, Issue 8, Page 2431-2455, August 2025.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Structural insights into the catalytic mechanism of the microcystin tailoring enzyme McyI. [PDF]

Commun Biol
Wang X, Yin Y, Cheng WL, Duan YF, Li YS, Wang J, Wang M, Dai HE, Liu L.   +8 more
europepmc   +1 more source

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Advanced Science, Volume 12, Issue 30, August 14, 2025.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia   +4 more
wiley   +1 more source

Identification and Abiotic Stress Expression Profiling of Malic Enzyme-Associated Genes in Maize (<i>Zea mays</i> L.). [PDF]

Plants (Basel)
Yan H, Li Y, Ma Z, Wang R, Zhou Y, Zhou W, He H, Wang X, Lian X, Dong X, Yao L.   +10 more
europepmc   +1 more source

Effect of Different Carbon Sources on the Ammonium Induction of Different Forms of NADP-Specific Glutamate Dehydrogenase in Chlorella sorokiniana Cells Cultured in the Light and Dark [PDF]

, 1986
Donna Prunkard, Newell F. Bascomb, William T. Molin, Robert R. Schmidt   +3 more
openalex   +1 more source

High‐Efficiency Carriers’ Separation Strategy Based Ultrasmall‐Bandgap CuWO4 Sono‐Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
This study prepares copper tungstate (CuWO4, CWO) nanoparticles for synergistic sono‐enhanced cuproptosis‐based cancer therapy. With an ultrasmall bandgap (1.71 eV), CWO facilitates efficient charge carrier separation under ultrasound, enhancing the generation of reactive oxygen species and the controlled release of Cu2+ ions cascade amplify oxidative ...
Lichao Zhu, Zhisheng Guo, Yu Luo, Haiyan Huang, Kexin Zhang, Bingbing Duan, Renmiao Peng, Haochen Yao, Chao Liang, Kaiyang Wang   +9 more
wiley   +1 more source

Crystal Structure of an Aldo-keto Reductase MGG_00097 from Magnaporthe grisea. [PDF]

Plant Pathol J
Huang X, Jiang H, Lin Y, Li X, Bi C, Qi S, Tang D, Wang Z, Lin S.   +8 more
europepmc   +1 more source

Histochemical localization of NADP-dependent dehydrogenase activity with four different tetrazolium salts.

, 1984
Cornelis J.F. Van Noorden, R. G. Butcher
openalex   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, Volume 12, Issue 31, August 21, 2025.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

Redox poise in R. rubrum phototrophic growth drives large-scale changes in macromolecular pathways. [PDF]

PLoS Comput Biol
Cannon WR, King E, Huening KA, North JA.
europepmc   +1 more source