Results 21 to 30 of about 141,947 (341)
The Scientific World Journal, 2012 NADPH regeneration appears to be essential in the mechanism of plant defence against oxidative stress. Plants contain several NADPH-generating dehydrogenases including isocitrate dehydrogenase (NADP-ICDH), glucose-6-phosphate dehydrogenase (G6PDH), 6 ...
Marina Leterrier +4 more
doaj +2 more sources
Mitochondrial NADP(H) generation is essential for proline biosynthesis
Science, 2021 Providing for protein synthesis Compartmentalization of metabolic processes into organelles can have important consequences. Zhu et al. examined the role of the coenzyme nicotinamide adenine dinucleotide phosphate (NADP+) and its reduced form (NADPH) in ...
Jiajun Zhu +8 more
semanticscholar +1 more source
Science Advances, 2022 Metastasizing cancer cells are able to withstand high levels of oxidative stress through mechanisms that are poorly understood. Here, we show that under various oxidative stress conditions, pancreatic cancer cells markedly expand NADPH and NADP+ pools ...
Yang Zhang +8 more
semanticscholar +1 more source
Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH and plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such as hemolytic anemia.
Xuepeng Wei +4 more
semanticscholar +1 more source
Mitochondrial NADP+ is essential for proline biosynthesis during cell growth
Nature Metabolism, 2021 Nicotinamide adenine dinucleotide phosphate (NADP+) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress.
D. H. Tran +10 more
semanticscholar +1 more source
Adjustment of light-responsive NADP dynamics in chloroplasts by stromal pH
Nature Communications, 2023 Cyclic electron transfer (CET) predominates when NADP+ is at basal levels, early in photosynthetic induction; however, the mechanism underlying the subsequent supply of NADP+ to fully drive steady-state linear electron transfer remains unclear.
Yusuke Fukuda +3 more
doaj +1 more source
NADP(H)-dependent biocatalysis without adding NADP(H)
Proceedings of the National Academy of Sciences, 2022 Isocitrate dehydrogenase 1 (IDH1) naturally copurifies and crystallizes in a resting state with a molecule of its exchangeable cofactor, NADP + /NADPH, bound in each monomer of the homodimer. We report electrochemical studies with IDH1 that exploit this property to reveal the massive advantage of nanoconfinement to ...
Herold, RA +3 more
openaire +2 more sources
Bio-Protocol, 2023 Chloroplast NADP-dependent malate dehydrogenase (NADP-MDH) is a redox regulated enzyme playing an important role in plant redox homeostasis. Leaf NADP-MDH activation level is considered a proxy for the chloroplast redox status.
Kevin Baudry +1 more
doaj +1 more source
Journal of Plant Interactions, 2022 High temperature inhibits the growth and development of maize (Zea mays L.) and wheat (Triticum aestivum L.) seedlings. The current study attempts to elucidate the underlying mechanisms of exogenous trehalose for the improvement of maize and wheat ...
Ziwei Zhang, Mei Sun, Yamin Gao, Yin Luo
doaj +1 more source
Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
core +4 more sources