Results 61 to 70 of about 72,905 (323)

Xylose Metabolism Perturbation in Yarrowia lipolytica for Efficient Succinic Acid Bioproduction from Lignocellulosic Biomass

Advanced Science, EarlyView.
This study engineers Yarrowia lipolytica to produce succinic acid (SA) from lignocellulosic biomass. Adaptive evolution and multi‐omics analysis identify regulators that alleviate xylose metabolic disorder. Multi‐copy integration of xylose metabolic genes resolves redox imbalances from a futile fatty acid cycle, producing high‐titer SA from corn stover
Yutao Zhong, Changyu Shang, Jinhong Gu, Huilin Tao, Xuemei Lu, Jin Hou, Zhiyong Cui, Qingsheng Qi   +7 more
wiley   +1 more source

Dynamic and Static Regulation of Nicotinamide Adenine Dinucleotide Phosphate: Strategies, Challenges, and Future Directions in Metabolic Engineering

Molecules
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial cofactor in metabolic networks. The efficient regeneration of NADPH is one of the limiting factors for productivity in biotransformation processes.
Nana Ding, Zenan Yuan, Lei Sun, Lianghong Yin   +3 more
doaj   +1 more source

Cytosolic Isocitrate Dehydrogenase from Arabidopsis thaliana Is Regulated by Glutathionylation

Antioxidants, 2019
NADP-dependent (Nicotinamide Adénine Dinucléotide Phosphate-dependent) isocitrate dehydrogenases (NADP-ICDH) are metabolic enzymes involved in 2-oxoglutarate biosynthesis, but they also supply cells with NADPH. Different NADP-ICDH genes are
Adnan Khan Niazi, Laetitia Bariat, Christophe Riondet, Christine Carapito, Amna Mhamdi, Graham Noctor, Jean-Philippe Reichheld   +6 more
doaj   +1 more source

A Novel Type II NAD+-Specific Isocitrate Dehydrogenase from the Marine Bacterium Congregibacter litoralis KT71. [PDF]

PLoS ONE, 2015
In most living organisms, isocitrate dehydrogenases (IDHs) convert isocitrate into ɑ-ketoglutarate (ɑ-KG). Phylogenetic analyses divide the IDH protein family into two subgroups: types I and II. Based on cofactor usage, IDHs are either NAD+-specific (NAD-
Ming-Cai Wu, Chang-Qing Tian, Hong-Mei Cheng, Lei Xu, Peng Wang, Guo-Ping Zhu   +5 more
doaj   +1 more source

Two functionally distinct NADP+-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus

Journal of Biological Chemistry, 2017
Electron bifurcation has recently gained acceptance as the third mechanism of energy conservation in which energy is conserved through the coupling of exergonic and endergonic reactions.
Diep Nguyen, G. Schut, O. Zadvornyy, Monika Tokmina-Lukaszewska, S. Poudel, G. Lipscomb, Leslie A. Adams, Jessica T. Dinsmore, W. Nixon, E. Boyd, B. Bothner, J. W. Peters, M. Adams   +12 more
semanticscholar   +1 more source

Association of ferredoxin-NADP+ reductase with NADP(H) specificity and oxidation-reduction properties. [PDF]

Journal of Biological Chemistry, 1986
The equilibrium properties of the NADP+ binding site of ferredoxin-NADP+ reductase (FNR, or Fd-NADP+ reductase) were examined with regard to specificity in binding, and with regard to the oxidation-reduction properties of the FNR.NADP+ complex. With the exception of 3'-NADP+, only adenosine nucleotides with a 2'-adenosyl phosphate bound to Fd-NADP ...
C J Batie, H Kamin
openaire   +2 more sources

Coenzyme Engineering of a Hyperthermophilic 6-Phosphogluconate Dehydrogenase from NADP+ to NAD+ with Its Application to Biobatteries

Scientific Reports, 2016
Engineering the coenzyme specificity of redox enzymes plays an important role in metabolic engineering, synthetic biology, and biocatalysis, but it has rarely been applied to bioelectrochemistry.
Hui Chen, Zhiguang Zhu, Rui Huang, Y. Zhang   +3 more
semanticscholar   +1 more source

Characterization of Organic Acid Metabolism and Expression of Related Genes During Fruit Development of Actinidia eriantha ‘Ganmi 6’

Plants, 2020
Studies on organic acid metabolism have been mainly concentrated on the fruit, whereas, few have focused on the mechanism of high organic acids content in the fruit of Actinidia eriantha.
Zhiqiang Jiang, Qing Huang, Dongfeng Jia, Min Zhong, Junjie Tao, Guanglian Liao, Chunhui Huang, Xiaobiao Xu   +7 more
doaj   +1 more source

The absent presence of disability in British higher education

British Educational Research Journal, EarlyView.
Abstract Rates of disability disclosure are steadily increasing in British higher education (HE), with 18% of the student population having a known disability in 2023/24. It might be assumed that progress is being made with increased representation, rights and support for disabled students.
G. Koutsouris, L. Stentiford, E. Dimitrellou, Z. Yu, Pujaningsih, N. Azizah   +5 more
wiley   +1 more source

Cytotoxic Activity of Opopanax hispidus (Friv.) Griseb.: Characterization of a New Chalcone‐type Compound

Chemistry &Biodiversity, EarlyView.
ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban, İpek Süntar, Perihan Gürbüz, Esra Emerce, Osman Tugay, Şengül Dilem Doğan, Beyza Hamur, Ahmet Ceyhan Gören   +7 more
wiley   +1 more source