Results 81 to 90 of about 75,190 (277)
NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
Nature Communications, 2019 Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an ...
Chunjing Bian +9 more
doaj +1 more source
Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration
Biotechnology and Bioengineering, EarlyView.ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi +2 more
wiley +1 more source
Scale‐Down Platforms for Process‐Oriented Enzyme Screening Using Microfluidics
Biotechnology and Bioengineering, EarlyView.ABSTRACT Enzyme screening platforms are typically evaluated based on their throughput and analytical performance rather than their ability to mimic the conditions encountered at large scale. In bioreactors, enzymes experience gradients in substrate concentration, oxygen availability, pH, temperature, and interfacial exposure, caused by imperfect mixing
Maria I. Rodriguez‐Torres +5 more
wiley +1 more source
Biological roles of crop NADP-malic enzymes and molecular mechanisms involved in abiotic stress
, 2011 The abiotic stress tolerance of plants is very important for plant growth, development, survival and functional performance. NADP-ME is one of the most important enzymes in plants.
Shao Hong-Bo +5 more
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Zeitschrift für Naturforschung B, 1972 Diaphorase and transhydrogenase activities (system NADPH; dichlorophenolindophenol and NADPH;NAD, respectively) of ferredoxin-NADP reductase are increased by ferredoxin. Reduced thionicotinamide-NADP (TN-NADPH) only slightly inhibits these activities with no ferredoxin present in the assay, but the activity increments in the presence of ferredoxin are ...
openaire +2 more sources
Apollo-NADP+ in 3D: Investigating In Vivo NADPH/NADP+ Redox Dynamics in Zebrafish Pancreatic β Cells [PDF]
The insulin-secreting β cells of the pancreas show low pentose phosphate pathway (PPP) activity, which is the main source of NADP+ reduction for NADPH generation in many other cell types.
Bui, Cindy
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The biocatalytic production of nicotinic acid using nitrilases has emerged as a promising alternative to conventional chemical synthesis, offering improved selectivity and environmental sustainability. In this study, we developed a continuous‐flow millireactor system employing Escherichia coli cells expressing a nitrilase from Paraburkholderia
Jonathan Bassut +8 more
wiley +1 more source
Abundance of NADP-dependent enzymes in plants [PDF]
, 2010 NADPH is an important molecule in plant metabolism. It is an indispensable substrate for many processes; participates in redox balance of the cell and it is a part of antioxidant defense system in plants.
Kovaľová, Terézia
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BMEMat, EarlyView.ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning +10 more
wiley +1 more source
National Atmospheric Deposition Program 2010 Annual summary [PDF]
, 2009 At the NADP Fall 2010 Meeting and Scientific Symposium, the NADP voted to approve the Ammonia Monitoring Network (AMoN) as the fifth NADP network.
National Atmospheric Deposition Program
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