NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression
Nature Communications, 2019 Cancer cells respond differently to inhibitors of Poly (ADP-ribose) polymerase. Here the authors reveal that ovarian cancer cells with higher cellular NADP+ levels are more sensitive to clinically relevant PARP1 inhibitors and show that NADP+ act as an ...
Chunjing Bian +9 more
doaj +1 more source
Zeitschrift für Naturforschung B, 1972 Diaphorase and transhydrogenase activities (system NADPH; dichlorophenolindophenol and NADPH;NAD, respectively) of ferredoxin-NADP reductase are increased by ferredoxin. Reduced thionicotinamide-NADP (TN-NADPH) only slightly inhibits these activities with no ferredoxin present in the assay, but the activity increments in the presence of ferredoxin are ...
openaire +2 more sources
Pest Management Science, EarlyView.Integrated GWAS and transcriptomics in a Canadian waterhemp biotype reveal mesotrione resistance is polygenic and metabolically driven. Significant SNPs and 187 herbicide‐responsive genes point to enhanced redox homeostasis, glutathione‐linked detoxification, lipid/secondary metabolism, and oxidative stress responses. Resistance arises from coordinated,
Martin Laforest +6 more
wiley +1 more source
Induction Kinetics of Photosystem I-Activated P700 Oxidation in Plant Leaves and Their Dependence on Pre-Energization [PDF]
, 2010 Absorbance changes ¿A 810 were measured in pea (Pisum sativum L., cv. Premium) leaves to track redox transients of chlorophyll P700 during and after irradiation with far red (FR) light under various preillumination conditions in the absence and presence ...
Bulychev, A.A., Vredenberg, W.J.
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Thirty years of glyphosate‐resistant crops and weeds: Current situation and future prospects
Pest Management Science, EarlyView.Since 1996, when the first glyphosate‐resistant crop was commercialized and the first resistant weed was reported, resistance has expanded globally. This review analyzes emergence patterns across weed species, crops, regions, resistance mechanisms, and herbicides.
Ricardo Alcántara‐de la Cruz +7 more
wiley +1 more source
Effects of mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency on fructose-induced obesity in mice [PDF]
, 2018 Obesity prevalence in the United States continues to increase and is associated with health consequences such as type 2 diabetes, hypertension, atherosclerosis, and hyperlipidemia.
Beane, Kaleigh Elizabeth +1 more
core +2 more sources
The solution space of metabolic networks: producibility, robustness and fluctuations [PDF]
, 2010 Flux analysis is a class of constraint-based approaches to the study of biochemical reaction networks: they are based on determining the reaction flux configurations compatible with given stoichiometric and thermodynamic constraints.
A De Martino +13 more
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Journal of Forensic Sciences, EarlyView.Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park +6 more
wiley +1 more source
Mercury deposition in southern New Hampshire, 2006–2009 [PDF]
, 2011 The atmospheric deposition of mercury (Hg) occurs via several mechanisms including wet, dry, and occult processes. In an effort to understand the atmospheric cycling and seasonal depositional characteristics of Hg, event-based wet deposition samples and ...
Bryce, J. G. +3 more
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In Situ Association of Calvin Cycle Enzymes, Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase Activase, Ferredoxin-NADP+ Reductase, and Nitrite Reductase with Thylakoid and Pyrenoid Membranes of Chlamydomonas reinhardtii Chloroplasts as Revealed by Immunoelectron Microscopy [PDF]
, 1995 K.-H. Süss +2 more
openalex +1 more source