Homeostatic regulation of NAD(H) and NADP(H) in cells [PDF]
Genes and DiseasesNicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and nicotinamide adenine dinucleotide phosphate (NADP+)/reduced NADP+ (NADPH) are essential metabolites involved in multiple metabolic pathways and cellular processes.
Pingfeng Zhang
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NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis [PDF]
Redox Biology, 2023 Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +11 more
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NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems [PDF]
Nature Communications, 2023 NADP(H) is a central metabolic hub providing reducing equivalents to multiple biosynthetic, regulatory and antioxidative pathways in all living organisms.
Pamela E. Molinari +14 more
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NADP(H) allosterically regulates the interaction between ferredoxin and ferredoxin‐NADP+ reductase [PDF]
FEBS Open Bio, 2019 Ferredoxin‐NADP+ reductase (FNR) in plants receives electrons from ferredoxin (Fd) at the end of the photosynthetic electron transfer chain and converts NADP+ to NADPH. The interaction between Fd and FNR in plants was previously shown to be attenuated by
Yoko Kimata‐Ariga +6 more
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Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors [PDF]
Cell Regeneration, 2022 Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs.
Ting Li +5 more
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Dynamic Preference for NADP/H Cofactor Binding/Release in E. coli YqhD Oxidoreductase [PDF]
Molecules, 2021 YqhD, an E. coli alcohol/aldehyde oxidoreductase, is an enzyme able to produce valuable bio-renewable fuels and fine chemicals from a broad range of starting materials.
Rajni Verma +2 more
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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism [PDF]
Antioxidants and Redox Signaling, 2018 The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular redox homeostasis and for modulating numerous biological events, including cellular metabolism. Deficiency or imbalance of these two redox couples has been associated with many pathological disorders ...
Wusheng Xiao +2 more
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MeNADP-ME3 Confers Salt and Drought Tolerance in Arabidopsis and Drives Functional Diversification of the NADP-ME Family in Cassava [PDF]
Current Issues in Molecular BiologyAs a typical C3-C4 intermediate plant, cassava (Manihot esculenta Crantz) exhibits high photosynthetic efficiency and low photorespiration. NADP-malic enzyme (NADP-ME) is a key enzyme in the C4 photosynthetic pathway that provides elevated CO2 ...
Shuwen Wu +5 more
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Glutamate dehydrogenases in fungi: From biology to biotechnology [PDF]
Fungal Biology and BiotechnologyGlutamate dehydrogenases (GDH; EC 1.4.1.2 and EC 1.4.1.4) play a pivotal role in fungal nitrogen metabolism by catalyzing the reversible conversion of 2-ketoglutarate to L-glutamate. In fungi, NAD- as well as NADP-dependent GDHs function at the interface
Ejaj K. Pathan +3 more
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Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells [PDF]
Nature CommunicationsT cell metabolism increases upon activation, underpinning immune effector functions. Nicotinamide adenine dinucleotide (NAD/H) is an essential redox cofactor for glycolysis and mitochondrial substrate oxidation.
Victoria Stavrou +21 more
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