NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis [PDF]
Redox Biology, 2023 Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance.
Didem Ilter +11 more
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NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems [PDF]
Nature Communications, 2023 NADP(H) is a central metabolic hub providing reducing equivalents to multiple biosynthetic, regulatory and antioxidative pathways in all living organisms.
Pamela E. Molinari +14 more
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Homeostatic regulation of NAD(H) and NADP(H) in cells [PDF]
Genes and DiseasesNicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and nicotinamide adenine dinucleotide phosphate (NADP+)/reduced NADP+ (NADPH) are essential metabolites involved in multiple metabolic pathways and cellular processes.
Pingfeng Zhang
exaly +4 more sources
Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors [PDF]
Cell Regeneration, 2022 Cell metabolism plays vital roles in organismal development, but it has been much less studied than transcriptional and epigenetic control of developmental programs.
Ting Li +5 more
doaj +2 more sources
NADP(H) allosterically regulates the interaction between ferredoxin and ferredoxin‐NADP+ reductase [PDF]
FEBS Open Bio, 2019 Ferredoxin‐NADP+ reductase (FNR) in plants receives electrons from ferredoxin (Fd) at the end of the photosynthetic electron transfer chain and converts NADP+ to NADPH. The interaction between Fd and FNR in plants was previously shown to be attenuated by
Yoko Kimata‐Ariga +6 more
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Dynamic Preference for NADP/H Cofactor Binding/Release in E. coli YqhD Oxidoreductase [PDF]
Molecules, 2021 YqhD, an E. coli alcohol/aldehyde oxidoreductase, is an enzyme able to produce valuable bio-renewable fuels and fine chemicals from a broad range of starting materials.
Rajni Verma +2 more
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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism [PDF]
Antioxidants and Redox Signaling, 2018 Wusheng Xiao +2 more
exaly +2 more sources
Glutamate dehydrogenases in fungi: From biology to biotechnology [PDF]
Fungal Biology and BiotechnologyGlutamate dehydrogenases (GDH; EC 1.4.1.2 and EC 1.4.1.4) play a pivotal role in fungal nitrogen metabolism by catalyzing the reversible conversion of 2-ketoglutarate to L-glutamate. In fungi, NAD- as well as NADP-dependent GDHs function at the interface
Ejaj K. Pathan +3 more
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Mitochondrial NAD kinase in health and disease
Redox Biology, 2023 Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron carrier, plays crucial roles in numerous biological functions, including cellular metabolism and antioxidation.
Ren Zhang, Kezhong Zhang
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Frontiers in Bioengineering and Biotechnology, 2021 Nicotinamide adenine dinucleotide phosphate (NADP)-dependent dehydrogenases catalyze a range of chemical reactions useful for practical applications. However, their dependence on the costly cofactor, NAD(P)H remains a challenge which must be addressed ...
Gamal Nasser Abdel-Hady +11 more
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