Results 11 to 20 of about 56,952 (277)
NADP(H)-dependent biocatalysis without adding NADP(H). [PDF]
Proc Natl Acad Sci U S A, 2023 Significance Within cells, enzymes and cofactors catalyzing multistep processes (cascades) are often confined together—either in enclosures (e.g., organelles) or via physical association (metabolons).
Herold RA +3 more
europepmc +4 more sources
Malaria Journal, 2011 Background Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Engel Paul C +7 more
doaj +2 more sources
The Synthesis of Poly-L-Lysine-Succinyl-Nadp: An Analogue for Nadp/H
The International Journal of Artificial Organs, 1980 Poly-L-lysine-succinyl-NADP, an analogue for nicotinamide adenine dinucleotide phosphate (NADP/H), has been synthesized by linking NADP/H to poly-L-lysine hydrobromide.
S.S. Sofer, W.M. Southard, R.A. Wills
core +3 more sources
Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein [PDF]
Proceedings of the National Academy of Sciences, 2007 NAD(P) has long been known as an essential energy-carrying molecule in cells. Recent data, however, indicate that NAD(P) also plays critical signaling roles in regulating cellular functions.
Lu, Fei +10 more
core +3 more sources
Synthesis of 8-N3-[2'-32P]NADP(H), a new photoaffinity label for NADP(H)-specific enzymes [PDF]
FEBS Letters, 1990 The synthesis of the photoaffinity label 8-N3-[2'-32P]NADP+ is described. The synthesis consists of the following steps: first 8-N3-AMP is synthesized from AMP or ATP and then the 8-N3-AMP is coupled with NMN, using DCCD as coupling reagent. Finally, the
Hartog, A.F. +3 more
core +2 more sources
Crystal structure of the vertebrate NADP(H)-dependent alcohol dehydrogenase (ADH8)
Journal of Molecular Biology, 2015 The amphibian enzyme ADH8, previously named class IV-like, is the only known vertebrate alcohol dehydrogenase (ADH) with specificity towards NADP(H). The three-dimensional structures of ADH8 and of the binary complex ADH8-NADP+ have been now determined ...
Farrés, Jaume +5 more
core +4 more sources
Archives of Biochemistry and Biophysics, 2007 The mechanism of hydride transfer between Anabaena FNR and NADP+/H was analysed using for the first time stopped-flow photodiode array detection and global analysis deconvolution.
Scrutton, Nigel S. +7 more
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Biochemistry, 2009 The NADP-binding site of Plasmodium falciparum ferredoxin-NADP+ reductase contains two basic residues, His286 and Lys249, conserved within the Plasmodium genus, but not in other plant-type homologues.
M. Bolognesi +7 more
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Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2012 The role of the highly conserved C266 and L268 of pea ferredoxin–NADP+ reductase (FNR) in formation of the catalytically competent complex of the enzyme with NADP(H) was investigated.
Medina, Milagros +4 more
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Mitochondrial NADP(H) generation is essential for proline biosynthesis. [PDF]
Science, 2021 Providing for protein synthesis Compartmentalization of metabolic processes into organelles can have important consequences. Zhu et al. examined the role of the coenzyme nicotinamide adenine dinucleotide phosphate (NADP + ) and its reduced form (NADPH) in cultured human cells.
Zhu J +8 more
europepmc +4 more sources