Results 71 to 80 of about 122,170 (318)

Suppressing Glycerol‐3‐phosphate Phosphatase and Enhancing Glycerol‐3‐Phosphate Shuttle Flux Crucial for High‐Efficiency Fatty Acid Production in the Fast‐Growing Oleaginous Schizochytrium

open access: yesAdvanced Science, EarlyView.
This study establishes an efficient oleaginous heterotrophic microalga, Schizochytrium, through chassis optimization and metabolic engineering, significantly enhancing fatty acid titers and productivities. It also identifies a regulatory mechanism that coordinates biomass and lipid synthesis, providing a rational target for metabolic pathway rewiring ...
Fangzhong Wang   +7 more
wiley   +1 more source

Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines

open access: yesAdvanced Science, EarlyView.
An unusual IRED platform is reported, enabling efficient DKR via reductive amination without any evolutionary engineering. The system accommodates extremely sterically demanding substrates, including naphthyl and quinoline derivatives, delivering naphthyl‐aryl and quinoline‐aryl amine atropisomers with excellent efficiency and stereocontrol (over 80 ...
Zhichao Ni   +7 more
wiley   +1 more source

Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagra [PDF]

open access: yes, 2007
Population surveys for niacin deficiency are normally based on clinical signs or on biochemical measurements of urinary niacin metabolites. Status may also be determined by measurement of whole blood NAD and NADP concentrations. To compare these methods,
Cheung, E   +5 more
core   +2 more sources

Dynamic and Static Regulation of Nicotinamide Adenine Dinucleotide Phosphate: Strategies, Challenges, and Future Directions in Metabolic Engineering

open access: yesMolecules
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial cofactor in metabolic networks. The efficient regeneration of NADPH is one of the limiting factors for productivity in biotransformation processes.
Nana Ding   +3 more
doaj   +1 more source

Association of ferredoxin-NADP+ reductase with NADP(H) specificity and oxidation-reduction properties. [PDF]

open access: yesJournal of Biological Chemistry, 1986
The equilibrium properties of the NADP+ binding site of ferredoxin-NADP+ reductase (FNR, or Fd-NADP+ reductase) were examined with regard to specificity in binding, and with regard to the oxidation-reduction properties of the FNR.NADP+ complex. With the exception of 3'-NADP+, only adenosine nucleotides with a 2'-adenosyl phosphate bound to Fd-NADP ...
C J Batie, H Kamin
openaire   +2 more sources

Leaves play a central role in the adaptation of nitrogen and sulfur metabolism to ammonium nutrition in oilseed rape (Brassica napus) [PDF]

open access: yes, 2010
Background: The coordination between nitrogen (N) and sulfur (S) assimilation is required to suitably provide plants with organic compounds essential for their development and growth.
Aparicio-Tejo, Pedro M.   +7 more
core   +6 more sources

Antagonistic Regulation by CPN60A and CLPC1 of TRXL1 that Regulates MDH Activity Leading to Plant Disease Resistance and Thermotolerance

open access: yesCell Reports, 2020
Summary: Global warming and emerging plant diseases challenge agricultural food/feed production. We identify mechanism(s) regulating both plant thermotolerance and disease resistance.
Bikram Datt Pant   +4 more
doaj   +1 more source

The absent presence of disability in British higher education

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Rates of disability disclosure are steadily increasing in British higher education (HE), with 18% of the student population having a known disability in 2023/24. It might be assumed that progress is being made with increased representation, rights and support for disabled students.
G. Koutsouris   +5 more
wiley   +1 more source

Characterization of Organic Acid Metabolism and Expression of Related Genes During Fruit Development of Actinidia eriantha ‘Ganmi 6’

open access: yesPlants, 2020
Studies on organic acid metabolism have been mainly concentrated on the fruit, whereas, few have focused on the mechanism of high organic acids content in the fruit of Actinidia eriantha.
Zhiqiang Jiang   +7 more
doaj   +1 more source

Biochemical and molecular characterization of the isocitrate dehydrogenase with dual coenzyme specificity from the obligate methylotroph Methylobacillus Flagellatus. [PDF]

open access: yesPLoS ONE, 2017
The isocitrate dehydrogenase (MfIDH) with unique double coenzyme specificity from Methylobacillus flagellatus was purified and characterized, and its gene was cloned and overexpressed in E. coli as a fused protein.
Anastasia Y Romkina, Michael Y Kiriukhin
doaj   +1 more source

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