Results 91 to 100 of about 11,248,301 (236)

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Enzymatic Electrosynthesis for Sustainable CO2 Conversion: Advancing Circular Carbon Economy

Carbon Energy, EarlyView.
Enzymatic electrosynthesis (EES) offers molecular precision in synthesizing value‐added products from CO2. We highlight its distinct edge over alternative enzyme‐hybrid systems and analyze electron transfer pathways. Key strategies to overcome electron transfer bottlenecks and expand product diversity are addressed, and also data‐driven approaches for ...
Yan Xie, Jia Ouyang, Manu Suvarna, Xiangzhou Yuan, Matthew R. Hill, Uwe Bornscheuer, Huiyan Zhang, Yong Sik Ok   +7 more
wiley   +1 more source

Conformational Change in the NADP(H) Binding Domain of Transhydrogenase Defines Four States^†,‡

, 2016
Proton-translocating transhydrogenase (TH) couples direct and stereospecific hydride transfer between NAD(H) and NADP(H), bound to soluble domains dI and dIII, respectively, to proton translocation across a membrane bound domain, dII. The reaction occurs
Vidyasankar Sundaresan (2731615), Mutsuo Yamaguchi (2731618), Justin Chartron (2497807), C. David Stout (213073)   +3 more
core   +1 more source

A Naphthalene Monoimide Meisenheimer Complex as Strong Organic Hydride Donor for Metal‐Free CO2 Reduction

Chemistry – A European Journal, EarlyView.
A Meisenheimer complex derived from two‐fold reduction and protonation of naphthalene monoamide has been identified as a strong organic hydride donor which is able to reduce CO2. ABSTRACT Selective CO2 reduction to formate is challenging due to similar thermodynamics for the reaction to other products such as carbon monoxide and molecular hydrogen ...
C. Jasslie Nielsen, Catriona C. James, Maartje C. van Rijn, Bente Reus, Bettina Baumgartner, Sonja Pullen   +5 more
wiley   +1 more source

Exploring Regorafenib Responsiveness and Uncovering Molecular Mechanisms in Recurrent Glioblastoma Tumors through Longitudinal In Vitro Sampling

Cells
Glioblastoma, a deadly brain tumor, shows limited response to standard therapies like temozolomide (TMZ). Recent findings from the REGOMA trial underscore a significant survival improvement offered by Regorafenib (REGO) in recurrent glioblastoma.
Mariangela Morelli, Francesca Lessi, Sara Franceschi, Gianmarco Ferri, Manuel Giacomarra, Michele Menicagli, Carlo Gambacciani, Francesco Pieri, Francesco Pasqualetti, Nicola Montemurro, Paolo Aretini, Orazio Santo Santonocito, Anna Luisa Di Stefano, Chiara Maria Mazzanti   +13 more
doaj   +1 more source

NADP- und NAD-spezifische Isocitrat-Dehydrogenase in Hydrogenomonas eutropha Stamm H 16.

, 1972
Aus einem Rohextrakt von Hydrogenomonas eutropha Stamm H16-Fructosezellen wurden eine NADP- und eine NAD-spezifische Isocitrat-Dehydrogenase teilweise gereinigt und getrennt. Beide Enzyme sind in ihrer Affinität zum Isocitrat und zu NADP bzw.
Schlegel, H.G., Glaeser, H.
core   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, EarlyView.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4+ T cells

Nature Communications
T cell metabolism increases upon activation, underpinning immune effector functions. Nicotinamide adenine dinucleotide (NAD/H) is an essential redox cofactor for glycolysis and mitochondrial substrate oxidation.
Victoria Stavrou, Myah Ali, Nancy Gudgeon, Emma L. Bishop, Taylor Fulton-Ward, Bethany Turley, Silke Heising, Sally H. Mohamed, Sofia Hain, Lorna George, Minghao Deng, Jack McCowan, Lozan Sheriff, Scott P. Davies, Bryan Marzullo, Daniel A. Tennant, Craig L. Doig, David A. Bending, Ed W. Roberts, Gareth G. Lavery, Rebecca A. Drummond, Sarah Dimeloe   +21 more
doaj   +1 more source