Results 91 to 100 of about 56,952 (277)

An in silico analysis of the glutamate dehydrogenases of Teladorsagia circumcincta and Haemonchus contortus [PDF]

Journal of BioScience and Biotechnology, 2014
Nematode glutamate dehydrogenase (GDH) amino acid sequences are very highly conserved (68-99% identity) and are also very similar to those of the bovine and human enzymes (54-60% identity).
SIMON BROWN, NOORZAID MUHAMAD, LISA R. WALKER, KEVIN C. PEDLEY, DAVID C. SIMCOCK   +4 more
doaj  

Zinc ions selectively inhibit steps associated with binding and release of NADP(H) during turnover of proton-translocating transhydrogenase

, 2005
Transhydrogenase couples the redox reaction between NAD(H) and NADP(H) to proton translocation across a membrane. In membrane vesicles from Escherichia coli and Rhodospirillum rubrum, the transhydrogenase reaction (measured in the direction driving ...
Hafiz, A, Cotton, Nicholas, Jackson, J. Baz, Whitehead, Simon J., Whitehead, SJ, Hafiz, Abdul, Rossington, Karen E., Cotton, Nick P.J., Jackson, John, Rossington, KE   +9 more
core   +1 more source

Mitochondrial NADP+ is essential for proline biosynthesis during cell growth

, 2021
Nicotinamide adenine dinucleotide phosphate (NADP(+)) is vital to produce NADPH, a principal supplier of reducing power for biosynthesis of macromolecules and protection against oxidative stress.
Rushendhiran Kesavan, Halie Rion, Ralph J. DeBerardinis, Mona Hoseini Soflaee, Soflaee, Mona Hoseini, John A. Phillips, Vu, Hieu S., Solmonson, Ashley, DeBerardinis, Ralph J., Phillips, John A., Bezwada, Divya, Feng Cai, Tran, Diem H., Divya Bezwada, Cai, Feng, Kesavan, Rushendhiran, Hoxhaj, Gerta, Diem H. Tran, Rion, Halie, Ashley Solmonson, Hieu S. Vu, Gerta Hoxhaj   +21 more
core   +1 more source

Spray‐Dried Engineered Escherichia coli Whole‐Cell Biocatalysts Enable Cell Recycling and In Vivo α‐Ketoglutarate and NADPH Regeneration for Efficient Codeine Manufacture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT A recombinant whole‐cell biocatalytic approach provides several advantages over isolated enzymes, such as improved enzyme stability, in vivo cofactor regeneration, and the facilitation of cascade reactions within a single cell. Whole‐cell biocatalysis has gained attention in medicinal opioid production, due to its technical and economic ...
Ali Jahanian, Carlos Horacio Luna‐Flores, Xu Li, Sally L. Gras, Robert E. Speight   +4 more
wiley   +1 more source

Interactions between transhydrogenase and thio-nicotinamide analogues of NAD(H) and NADP(H) underline the importance of nucleotide confirmational changes in coupling to proton translocation

, 2003
Transhydrogenase couples the reduction of NADP(+) by NADH to inward proton translocation across mitochondrial and bacterial membranes. The coupling reactions occur within the protein by long distance conformational changes. In intact transhydrogenase and
Rodriques, DJ, Van Boxel, Gijsbert, Singh, Avtar, Venning, JD, Jackson, John, Quirk, Philip, White, Scott   +6 more
core   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia

, 2014
Dienoyl-CoA reductase (DECR) deficiency with hyperlysinemia is a rare disorder affecting the metabolism of polyunsaturated fatty acids and lysine. The molecular basis of this condition is currently unknown.
Gucsavas-Calikoglu, Muge, Wanders, Ronald J. A., Denis, Simone, Frazier, Dianne M., Houten, Sander M., van Kampen, Antoine H. C., Jongejan, Aldo, Bradley, Edward J., Baas, Frank, Hennekam, Raoul C. M., te Brinke, Heleen, Young, Sarah P., Millington, David S.   +12 more
core   +2 more sources

Transcriptional Isoforms of NAD+ kinase regulate oxidative stress resistance and melanoma metastasis

Redox Biology
Metastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade. Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their metabolic pathways to ...
Graciela Cascio, Kelsey N. Aguirre, Kellsey P. Church, Riley O. Hughes, Leona A. Nease, Ines Delclaux, Hannah J. Davis, Elena Piskounova   +7 more
doaj   +1 more source

Antibodies to the glutamate dehydrogenase of Plasmodium falciparum [PDF]

, 1986
Polyclonal antisera raised against Plasmodium knowlesi reacted with NADP-specific glutamate dehydrogenase (GLDH) of P. knowlesi, GLDH of P. falciparum and GLDH of Proteus spp. The antisera did not react with NAD(P) GLDH from bovine liver.
Cooksley, S, Wilson, R J, Hempelmann, E, Ling, I T, Bates, P A   +4 more
core  

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source