Results 71 to 80 of about 11,248,301 (236)
Advanced Science, EarlyView.Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai +12 more
wiley +1 more source
BMC Plant Biology, 2019 Background C4 plants have been classified into three subtypes based on the enzymes used to decarboxylate C4 acids in the bundle sheath cells (NADP-ME, NAD-ME and PEPCK pathways).
Viviane Cacefo +6 more
doaj +1 more source
Circadian rhythms are conserved biological timekeeping mechanisms crucial for the temporal compartmentalization of metabolic processes.
Xiaorong Fu +12 more
core +1 more source
Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein
, 2007 NAD(P) has long been known as an essential energy-carrying molecule in cells. Recent data, however, indicate that NAD(P) also plays critical signaling roles in regulating cellular functions.
Lu, Fei +10 more
core +1 more source
Advanced Science, EarlyView.The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li +9 more
wiley +1 more source
Disabled Student Support for England in 2017. How did we get here and where are we going? A brief history, commentary on current context and reflection on possible future directions. [PDF]
, 2017 Provision for disabled students studying in England’s HEIs is at a crossroads with the simultaneous review of the DSA and push towards embedded inclusive practices governed by social model principles of universal design for learning.
Martin, N, Wilson, L
core
Zinc ions selectively inhibit steps associated with binding and release of NADP(H) during turnover of proton-translocating transhydrogenase [PDF]
, 2005 Transhydrogenase couples the redox reaction between NAD(H) and NADP(H) to proton translocation across a membrane. In membrane vesicles from Escherichia coli and Rhodospirillum rubrum, the transhydrogenase reaction (measured in the direction driving ...
Hafiz, A +9 more
core +1 more source
Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease
Advanced Science, EarlyView.A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li +9 more
wiley +1 more source
Glutaredoxine reduzieren schnell Glutathionhydroper‐ und Glutathionpolysulfide
Angewandte Chemie, EarlyView.Glutaredoxine (Grx) reduzieren Glutathionpolysulfide (GSSnSG) schnell zu Glutathionhydroper/polysulfiden (GSSnH) oder GSSnH zu Wasserstoff(poly)sulfiden (H2Sn). Die Reduktion glutathionylierter Grx durch reduziertes Glutathion (GSH) liefert Glutathiondisulfid (GSSG).
Philipp Reinert +6 more
wiley +1 more source
Crystal structure of the vertebrate NADP(H)-dependent alcohol dehydrogenase (ADH8)
, 2015 The amphibian enzyme ADH8, previously named class IV-like, is the only known vertebrate alcohol dehydrogenase (ADH) with specificity towards NADP(H). The three-dimensional structures of ADH8 and of the binary complex ADH8-NADP+ have been now determined ...
Farrés, Jaume +5 more
core +1 more source