Results 51 to 60 of about 11,248,301 (236)

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Estudi estructural i cinètic de l'especificitat de coenzim d'una alcohol deshidrogenasa d'amfibi dependent de NADP(H) [PDF]

, 2004
Consultable des del TDXTítol obtingut de la portada digitalitzadaEls teixits gàstrics de l'amfibi Rana perezi expressen una alcohol deshidrogenasa (ADH8) dependent de NADP(H), una especificitat de coenzim única dintre de les ADHs de vertebrat.
Rosell i Febres, Albert
core   +1 more source

The Mitochondrial Protein MitoNEET as a Probe for the Allostery of Glutamate Dehydrogenase

Molecules, 2022
The proteins glutamate dehydrogenase (GDH) and mitoNEET are both targets of drug development efforts to treat metabolic disorders, cancer, and neurodegenerative diseases.
Chimere Nnatubeugo, Erica Johnson, Sarah Gisondi, Felicia Roland, Werner J. Geldenhuys, Michael A. Menze, Mary E. Konkle   +6 more
doaj   +1 more source

Interactions of the NADP(H)-Binding Domain III of Proton-Translocating Transhydrogenase from Escherichia coli with NADP(H) and the NAD(H)-Binding Domain I Studied by NMR and Site-Directed Mutagenesis^†

, 2016
Using the purified NADP(H)-binding domain of proton-translocating Escherichia coli transhydrogenase (ecIII) overexpressed in 15N- and 2H-labeled medium, together with the purified NAD(H)-binding domain from E.
Tomas Johansson (127325), Jan Rydström (2944920), Carina Johansson (2944917), Anders Bergkvist (2944923), B. Göran Karlsson (405542)   +4 more
core   +1 more source

SdrA, an NADP(H)-regenerating enzyme, is crucial for Coxiella burnetii to resist oxidative stress and replicate intracellularly [PDF]

, 2020
Coxiella burnetii, the causative agent of the zoonotic disease Q fever, is a Gram-negative bacterium that replicates inside macrophages within a highly oxidative vacuole.
Newton, HJ, Sansom, FM, Bitew, MA, Hofmann, J, Wawegama, NK, De Souza, DP   +5 more
core   +1 more source

Super‐Multiplexed Label‐Free Raman Imaging Uncovers Novel Testicular Metabolic Couplings for Residual Body and Spermatogonial Differentiation

Advanced Science, EarlyView.
Super‐multiplexed Label‐free Raman Imaging (SLRI) enables 2D/3D metabolic mapping of intact Drosophila testes. Moving beyond descriptive morphology, it establishes a multidimensional tool for tissue metabolic remodeling, and offers a generalizable platform for complex tissue analysis, with implications extending to development and disease. ABSTRACT The
Jiaxin Li, Xia Chen, Yujuan Qi, Chen Qiao, Qiuru Huang, Dan Zhao, Weiyi Qian, Li Di, Yi Shi, Xiangqi Hu, Yueyue Shao, Kehan Wang, Zhiyu Tang‐Yang, Hanzhi Zang, Yuwen Du, Anran Dong, Jinxiong Feng, Jiayun Chen, Ying Zheng, Xiaofang Tan, Xiaoyu Zhao, Zhonghua Shi, Bo Zheng, Jun Yu   +23 more
wiley   +1 more source

Effects of 1-Methylcyclopropene Treatment on the Quality and Malic Acid Metabolism of ‘Xiangjiao’ Plum under Low-Temperature Storage

Horticulturae, 2023
‘Xiangjiao’ plum (Prunus salicina Lindl.) is a stone fruit that is vulnerable to the chilling injury (CI) that is caused by low-temperature stress. The effects of 1-methylcyclopropene (1-MCP) and ethylene absorbent (EA) treatments on the fruit quality ...
Shutong Wu, Zhiqiang Zhu, Yunze Han, Shujuan Ji, Shunchang Cheng, Qian Zhou, Xin Zhou, Meilin Li, Baodong Wei   +8 more
doaj   +1 more source

Structural basis for the light regulation of chloroplast NADP malate dehydrogenase

, 2000
The activity of chloroplast NADP-malate dehydrogenase (NADP-MDH; EC 1.1.1.82) in both C-3 and C-4 plants is regulated by light intensity, In darkness, the activity of the enzyme can be less than 1% of the maximal activity found at high light intensities.
Carr, P. D., Trevanion, S. J., Verger, D., Ollis, D. L., Ashton, A. R.   +4 more
core   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM

Nature Communications, 2019
The original version of this Article contained an error in Fig. 1, in which the labels ‘NADP+’ and ‘NADPH + H+’ were incorrectly given as ‘NADPH’ and ‘NADPH+ + H+’, respectively. This has been corrected in both the PDF and HTML versions of the Article.
Shogo Mori, Allan H. Pang, Nishad Thamban Chandrika, Sylvie Garneau-Tsodikova, Oleg V. Tsodikov   +4 more
doaj   +1 more source