Results 51 to 60 of about 56,952 (277)

Physiological Significance of NAD Kinases in Cyanobacteria

Frontiers in Plant Science, 2019
Unicellular cyanobacteria are thought to be the evolutionary ancestors of plant chloroplasts and are widely used both for chemical production and as model organisms in studies of photosynthesis. Although most research focused on increasing reducing power
Yuuma Ishikawa, Maki Kawai-Yamada
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

NAMPT-mediated salvage synthesis of NAD+ controls morphofunctional changes of macrophages. [PDF]

PLoS ONE, 2014
Functional morphodynamic behavior of differentiated macrophages is strongly controlled by actin cytoskeleton rearrangements, a process in which also metabolic cofactors ATP and NAD(H) (i.e. NAD+ and NADH) and NADP(H) (i.e.
Gerda Venter, Frank T J J Oerlemans, Marieke Willemse, Mietske Wijers, Jack A M Fransen, Bé Wieringa   +5 more
doaj   +1 more source

Purification and characterisation of an acyclic monoterpene primary alcohol: NADP+ oxidoreductase from catmint (Nepeta racemosa)

, 1995
A soluble monoterpene primary alcohol:NADP+ oxidoreductase has been purified to apparent homogeneity from leaves of the catmint, Nepeta racemosa. The purified enzyme consisted of two polypeptides, with molecular masses of 42,000 and 40,000 Da, and ...
Pickett, J. A., Wallsgrove, Roger M., Smiley, D. W. M., Smiley, Diane W.M., Dawson, G. W., Wallsgrove, R. M., West, Jevon M., Pickett, John A., Hallahan, David L., Hamilton, J. G. C., Hallahan, D. L., West, J. M., Hamilton, James G.C., Dawson, Glenn W.   +13 more
core   +1 more source

Oppositely Charged Single Enzyme Nanogels Form Versatile Coacervates for Efficient Enzyme Cascade Catalysis

Advanced Materials, EarlyView.
Oppositely charged single enzyme nanogels (SENs) phase‐separate into bi‐enzymatic coacervate microdroplets, acting as both scaffold and functional units. By tuning SEN ratios, these coacervates create specific microenvironments that enable selective small‐molecule enrichment and efficient intermediate diffusion.
Andoni Rodriguez‐Abetxuko, Nadia A. Erkamp, Neshat Moslehi, Yannick H. A. Leurs, Lars Paffen, Işil Yeşil Gür, Jana Stojanović, Hugo Brasselet, Laura van der Weel, Ulf Hanefeld, Ilja K. Voets, Jan C. M. van Hest   +11 more
wiley   +1 more source

Glucose-6-Phosphate Dehydrogenase, ZwfA, a Dual Cofactor-Specific Isozyme Is Predominantly Involved in the Glucose Metabolism of Pseudomonas bharatica CSV86T

Microbiology Spectrum, 2022
Glucose-6-phosphate dehydrogenase (Zwf) is an important enzyme in glucose metabolism via the Entner-Doudoroff pathway and the first enzyme in the oxidative pentose-phosphate pathway. It generates NAD(P)H during the conversion of glucose-6-phosphate (G6P)
Bhavik A. Shah, Sravanti T. Kasarlawar, Prashant S. Phale   +2 more
doaj   +1 more source

Interactions of the NADP(H)-Binding Domain III of Proton-Translocating Transhydrogenase from Escherichia coli with NADP(H) and the NAD(H)-Binding Domain I Studied by NMR and Site-Directed Mutagenesis^†

, 2016
Using the purified NADP(H)-binding domain of proton-translocating Escherichia coli transhydrogenase (ecIII) overexpressed in 15N- and 2H-labeled medium, together with the purified NAD(H)-binding domain from E.
Tomas Johansson (127325), Jan Rydström (2944920), Carina Johansson (2944917), Anders Bergkvist (2944923), B. Göran Karlsson (405542)   +4 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Role of Histidine 78 of leaf ferredoxin in the interaction with ferredoxin-NADP+ reductase: regulation of pH dependency and negative cooperativity with NADP(H)

Bioscience, Biotechnology, and Biochemistry, 2022
ABSTRACT In chloroplast stroma, dynamic pH change occurs in response to fluctuating light conditions. We investigated the pH-dependent electron transfer activity between ferredoxin-NADP+ reductase (FNR) and ferredoxin (Fd) isoproteins from maize leaves.
Yoko, Kimata-Ariga, Karen, Fukuta, Masayuki, Miyata   +2 more
openaire   +2 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source