Results 141 to 150 of about 239,596 (347)

Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase.

open access: hybrid, 1979
Harry G. Enoch, Philipp Strittmatter
openalex   +1 more source

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

open access: yesCirculation Research, 1994
K. Griendling   +3 more
semanticscholar   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

open access: yesAdvanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi   +4 more
wiley   +1 more source

Mechanotransduction in Shaping Immunity: Pathways, Crosstalk, and Pathophysiological Relevance

open access: yesAdvanced Science, EarlyView.
This review comprehensively summarizes the role of mechanotransduction in shaping immunity. It details how immune cells respond to biomechanical cues via mechanotransduction cascades and emphasizes the mechanical crosstalks within the immune microenvironment. The emerging significance of mechanoimmunology in both health and diseases is also highlighted.
Ruijiao Yan   +7 more
wiley   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

open access: yesAdvanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang   +28 more
wiley   +1 more source

Trimetallic Nanozyme‐Embedded Smart Hydrogel Enables NIR‐Controlled Bacterial Killing and Oxidative Stress Alleviation

open access: yesAdvanced Science, EarlyView.
A microenvironment‐responsive hydrogel is developed incorporating polymyxin B‐modified AuMnCu nanozymes and dual drugs (tannic acid and tobramycin). At infection sites, it generates ROS, releases drugs responsively, and enhances mild photothermal action to disrupt bacterial redox balance.
Zehui Xiao   +5 more
wiley   +1 more source

P450 Enzyme LyoI Performs Hydro‐2,2′‐Bifuran Oxidation in the Polyether Ionophore Lysocellin

open access: yesAngewandte Chemie, EarlyView.
In a study of the biosynthesis of the polyether ionophore lysocellin, the P450 enzyme LyoI was found to catalyze a rare oxidation of a hydro‐2,2′‐bifuran moiety to its hemiketal form. The oxidation was identified as the key for unlocking the bioactivity of lysocellin.
Michelle H. Rasmussen   +4 more
wiley   +2 more sources

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