Results 151 to 160 of about 239,596 (347)

Protein kinase C and the activation of the human neutrophil NADPH- oxidase [PDF]

, 1987
AI Tauber
openalex   +1 more source

Tumor Microenvironment‐Responsive Nanomedicines for Potentiating Cancer Immunotherapy

Advanced Science, EarlyView.
Strategies for TME‐responsive Nanomaterials to Potentiate Cancer Immunotherapy. Abstract Immunotherapy has emerged as a transformative paradigm in oncology, yet its clinical efficacy remains constrained by the immunosuppressive tumor microenvironment and inadequate spatiotemporal control of existing modalities, resulting in suboptimal patient response ...
Qianqian Huang, Fan Tong, Jiantao Chen, Muzaffar Kayumov, Yue Lv, Yajun Shi, Bengui Ye, Huile Gao   +7 more
wiley   +1 more source

Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined

Aggregate, EarlyView.
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding   +8 more
wiley   +1 more source

Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron‐Deficient Aromatic d‐Amino Acids

Angewandte Chemie, EarlyView.
Phenylalanine ammonia lyases (PALs) were engineered to switch enantioselectivity, enabling hydroamination for the direct synthesis of electron‐deficient aromatic d‐amino acids (d‐AA). Structure‐guided engineering provided PAL variants with broad substrate scope, high activity, and excellent d‐selectivity, broadening the utility of PALs in asymmetric ...
Ivan Buslov, Sarah Desmons, Weijin Wang, Laura Elena Massaad, Xile Hu   +4 more
wiley   +2 more sources

The association between cytochrome P‐450 and NADPH‐cytochrome P‐450 reductase in microsomal membrane

, 1975
Chung S. Yang
openalex   +1 more source

The effects of dietary lipid and phenobarbitone on the production and utilization of NADPH in the liver. A combined biochemical and quantitative cytochemical study [PDF]

, 1981
Martyn T. Smith, E.D. Wills
openalex   +1 more source

Identification and Characterization of a Novel Biallelic SLC12A2 Variant Associated With Kilquist Syndrome (OMIM #619080)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study presents the case of a child with multiple congenital anomalies, severe hypotonia, and profound bilateral sensorineural hearing loss. Functional bioenergetic assessments showed no significant mitochondrial respiratory defects, and riboflavin (Rf) status evaluation excluded a deficiency in Rf transporters as a cause of hearing loss ...
Piero Leone, Alessia Nisco, Luciana de Gennaro, Maria Tolomeo, Elisa Lorefice, Giuseppe Petrosillo, Silvia Russo, Donatella De Giovanni, Claudia Rita Catacchio, Francesca Romana Lepri, Mario Ventura, Simonetta Simonetti, Albina Tummolo, Maria Barile   +13 more
wiley   +1 more source

Naphthalimide‐Based Type‐I Nano‐Photosensitizers for Enhanced Antitumor Photodynamic Therapy: H2S Synergistically Regulates PeT and Self‐Assembly

Angewandte Chemie, EarlyView.
Here, we introduce a design strategy for activated photosensitizers (PSs) wherein photoinduced electron transfer (PeT) is combined with a process of self‐assembly that can be regulated by endogenous H2S—a tumor‐associated biomarker to favor Type‐I photochemical reactions.
Huiyu Niu, Songnan Wang, Yang Liu, Nana Ma, Shuaiwei Cheng, Beidou Feng, Hyunsun Jeong, Yonggang Yang, Ge Wang, Tony D. James, Juyoung Yoon, Jonathan L. Sessler, Hua Zhang   +12 more
wiley   +2 more sources

Purification and characterization of NADPH-dependent flavin reductase. An enzyme required for the activation of chorismate synthase in Bacillus subtilis.

, 1978
N. Hasan, E.W. Nester
openalex   +1 more source

Histochemical characterization of neuronal NADPH-diaphorase. [PDF]

, 1989
Bruce T. Hope, S.R. Vincent
openalex   +1 more source