Results 141 to 150 of about 832 (217)
Molecular insights and translational opportunities to enhance heat tolerance in rice
The Plant Genome, Volume 19, Issue 3, September 2026.Abstract Heat stress is an increasingly serious threat to rice (Oryza sativa L.) productivity, yet the genetic and regulatory architecture underlying thermotolerance remain poorly resolved and fragmented across studies. Earlier research focused on individual pathways or specific developmental stages; however, recent advances now support an integrated ...
Prabhat Rana +7 more
wiley +1 more source
New Phytologist, Volume 251, Issue 6, Page 3072-3079, September 2026.Predicted evolutionary history of GAPA (blue squares), CP12 (red circles), and GAPB (represented as a fusion of a blue square and half red circle) across the Viridiplantae.
Alex P. Mann +3 more
wiley +1 more source
Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri +13 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Proline‐derived Au(I)–NHC complexes display potent anticancer activity against lung and triple‐negative breast cancer cells. The cationic complexes promote DNA intercalation, thioredoxin reductase inhibition, ROS overproduction, and mitochondrial membrane depolarization, ultimately triggering apoptotic cell death through a multimodal mechanism of ...
Giacomo Cassarà +3 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.A Goodfellowiella coeruleoviolacea Imine Reductase is here reported as a novel enzyme for biocatalytic application in chiral amine synthesis. Deep eutectic solvents have been used to increase substrate loadings, up to 150 mM, and boost enzymatic activity. Reaction scope and scale‐up procedure showcased the protocol applicability.
Federica De Nardi +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy
Advanced Science, Volume 13, Issue 45, 13 August 2026.ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang +10 more
wiley +1 more source
The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution
BioEssays, Volume 48, Issue 8, August 2026.p53 is an adaptive processor positioned at the interface between metabolism and the tumor microenvironment. By integrating nutrient, mechanical, inflammatory, and redox cues while reciprocally remodeling metabolism, stromal and immune compartments, and cancer cell plasticity, WT and mutant p53 orchestrate cell competition, tumor evolution, metastasis ...
Sebastien M. Joruiz +3 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background Acute myeloid leukemia (AML) is an aggressive and molecularly heterogeneous hematologic malignancy associated with poor clinical outcomes, particularly in elderly and high‐risk patients. Increasing evidence suggests that metabolic reprogramming plays a critical role in leukemia progression, immune dysregulation, and therapeutic ...
Samaneh Ramezani +3 more
wiley +1 more source
Neutrophil‐based immunotherapy: A metabolic lens on mechanisms and therapeutic implications
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.TAN metabolic reprogramming critically contributes to tumour immune evasion. A 4‑Tier TAN‑MetaC classification framework is proposed, along with an overview of translational opportunities and bottlenecks for TAN metabolism‑targeted immunotherapies. Abstract Background Tumor‐associated neutrophils (TANs) serve as pivotal immune modulators in the tumor ...
Wenchao Xu +4 more
wiley +1 more source