Results 111 to 120 of about 249,924 (296)

The free fatty acid 2 receptor regulates C5a induced neutrophil superoxide production and its sensitivity to inhibition by the antagonist avacopan

Frontiers in Immunology
IntroductionReceptor transactivation is a novel signaling mechanism used by several different neutrophil G protein-coupled receptors (GPCRs) to activate an allosterically modulated receptor that recognizes short chain free fatty acids.
Zahra Khan, Zahra Khan, Neele K. Levin, Claes Dahlgren, Martina Sundqvist, Fariha Khan, Huamei Forsman, Huamei Forsman, Lena Björkman   +8 more
doaj   +1 more source

Expression of NADPH oxidase in human pancreatic islets [PDF]

, 2012
Aims: NADPH oxidase (NOX) is a known source of superoxide anions in phagocytic and non-phagocytic cells. In this study, the presence of this enzyme in human pancreatic islets and the importance of NADPH oxidase in human beta-cell function were ...
Labriola, Leticia, Graciano, Maria Fernanda Rodrigues, Rebelato, Eduardo, Garay-Malpartida, Humberto M., Curi, Rui, Malpartida, Humberto Miguel Garay, Graciano, Maria Fernanda R., Sogayar, Mari C., Sogayar, Mari Cleide, Guia, Thiago Rennó dos Mares, Carpinelli, Angelo Rafael, Oliveira, Eduardo Rebelato Lopes de, Mares-Guia, Thiago R., Britto, Luiz Roberto Giorgetti de, Britto, Luiz R.G., Carpinelli, Angelo R.   +15 more
core   +1 more source

NADPH oxidase in human lung fibroblasts

Journal of Biomedical Science, 2004
Reactive oxygen species produced by NADPH oxidase appear to play a role in the response of human lung fibroblast cells to rhinovirus infection. The purpose of the following studies was to characterize the NADPH oxidase components in these cells, to examine the effect of rhinovirus challenge on the expression of these proteins, and to confirm previous ...
Gursev S, Dhaunsi, Manjeet Kaur, Paintlia, Jaspal, Kaur, Ronald B, Turner   +3 more
openaire   +2 more sources

NADPH oxidase 4 (NOX4) as a biomarker and therapeutic target in neurodegenerative diseases

Neural Regeneration Research
Diseases like Alzheimer's and Parkinson's diseases are defined by inflammation and the damage neurons undergo due to oxidative stress. A primary reactive oxygen species contributor in the central nervous system, NADPH oxidase 4, is viewed as a potential ...
Napissara Boonpraman, Sun Shin Yi
doaj   +1 more source

A Role for Reactive Oxygen Species Produced by NADPH Oxidases in the Embryo and Aleurone Cells in Barley Seed Germination.

PLoS ONE, 2015
Reactive oxygen species (ROS) promote the germination of several seeds, and antioxidants suppress it. However, questions remain regarding the role and production mechanism of ROS in seed germination. Here, we focused on NADPH oxidases, which produce ROS.
Yushi Ishibashi, Shinsuke Kasa, Masatsugu Sakamoto, Nozomi Aoki, Kyohei Kai, Takashi Yuasa, Atsushi Hanada, Shinjiro Yamaguchi, Mari Iwaya-Inoue   +8 more
doaj   +1 more source

Regulation of NADPH Oxidases [PDF]

Circulation Research, 2006
The role for reactive oxygen species (ROS) in cellular (patho)physiology, in particular in signal transduction, is increasingly recognized. The family of NADPH oxidases (NOXes) plays an important role in the production of ROS in response to receptor agonists such as growth factors or inflammatory cytokines that signal through the Rho-like ...
openaire   +2 more sources

Self-inactivating gammaretroviral vectors for the gene therapy of chronic granulomatous disease [PDF]

, 2008
Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency characterized by defective intracellular oxidative killing of ingested invading microbes by PMN and monocytes.
Moreno Carranza, Bibiana
core  

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

NADPH Oxidase Overactivity Underlies Telomere Shortening in Human Atherosclerosis

, 2020
Telomere shortening and oxidative stress are involved in the pathogenesis of atherosclerosis. Different studies have shown that phagocytic NADPH oxidase is associated with this disease. This study aimed to investigate the association between phagocytic
Beloqui, O. (Óscar), Montero, L. (Laura), Marqués, J. (Javier), Fortuño, A. (Ana), Orbe, J. (Josune), Pejenaute-Martínez-de-Lizarrondo, Á. (Álvaro), Marti-del-Moral, A. (Amelia), Cortés, A. (Adriana), Zalba, G. (Guillermo)   +8 more
core   +1 more source

Artificial Cell Catalysts for Biotransformation: Design Principles and Process Integration

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Artificial cell catalysts are emerging as programmable biocatalytic platforms for sustainable molecular conversion. By reconstituting enzymes and functional modules within synthetic compartments, they combine the selectivity of biological catalysis with the design flexibility of synthetic materials.
Iori Kobayashi, Shogo Yoshimoto, Katsutoshi Hori   +2 more
wiley   +1 more source