Results 121 to 130 of about 249,924 (296)

Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91-phox and p22-phox in Endothelial Cells [PDF]

, 2000
The production of reactive oxygen species (ROS) within endothelial cells may have several effects, including alterations in the activity of paracrine factors, gene expression, apoptosis, and cellular injury.
Blayney, Lynda, Shah, A M, Blayney, L, Bayraktutan, Ulvi, Bayraktutan, U, Shah, Ajay   +5 more
core  

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Regulation of NADPH oxidase activity in phagocytes: relationship between FAD/NADPH binding and oxidase complex assembly.

, 2010
International audienceThe X(+)-linked chronic granulomatous disease (X(+)-CGD) variants are natural mutants characterized by defective NADPH oxidase activity but with normal Nox2 expression.
Didier Grunwald, Picciocchi, Antoine, Sylvain Beaumel, Antoine Picciocchi, Beaumel, Sylvain, Franck Fieschi, Marie-Claire Dagher, Franck Debeurme, Marie-José Stasia, Stasia, Marie José, Grunwald, Didier, Debeurme, Franck, Dagher, Marie-Claire, Fieschi, Franck   +13 more
core   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source

The physicochemical properties of membranes correlate with the NADPH oxidase activity

, 2017
International audienceBackground: Phagocytes kill ingested microbes by exposure to high concentrations of toxic reactive species generated by NADPH-oxidases.
Souabni, Hager, Houée-Levin, Chantal, Wien, Frank, Refregiers, Matthieu,, Baciou, Laura, Bizouarn, Tania   +5 more
core   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source

Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics

, 2021
Mark F McCarty,1 James J DiNicolantonio,2 Aaron Lerner3 1Catalytic Longevity Foundation, San Diego, CA, USA; 2Department of Preventive Cardiology, Saint Luke’s Mid America Heart Institute, Kansas, MO, USA; 3Chaim Sheba Medical Center, The ...
Lerner A, McCarty MF, DiNicolantonio JJ
core  

Beneficial effects of antioxidants on neutrophil extracellular trap formation in atherosclerosis

Archives of Medical Science
Introduction Neutrophils have been implicated in the pathogenesis of atherosclerosis in multiple studies. This study aimed to determine the effects of flavonoids (quercetin and luteolin) and vitamin C on neutrophil extracellular trap (NET) formation and ...
Dorota Dąbrowska-Zagroba, Marzena Garley, Wioletta Ratajczak-Wrona, Jolanta Sawicka-Powierza, Kamil Grubczak, Piotr Radziwon, Sławomir Wołczyński, Ewa Jabłońska   +7 more
doaj   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Changes in NADPH oxidase expression and activity.

, 2013
(A). Changes in P47phox mRNA expression in frontal cerebral cortex in wild type mice exposed to IH (n = 8 per experimental group ...
Deepti Nair (351053), Yang Wang (5921), David Gozal (306326), Ehab A. Dayyat (351054), Shelley X. Zhang (351055)   +4 more
core   +1 more source