Results 71 to 80 of about 424,484 (404)

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor.

Antioxidants and Redox Signaling, 2015
AIMS The NADPH oxidase (NOX) family of enzymes catalyzes the formation of reactive oxygen species (ROS). NOX enzymes not only have a key role in a variety of physiological processes but also contribute to oxidative stress in certain disease states.
K. Hirano, Woei Shin Chen, Adeline L.W. Chueng, Angela A. Dunne, T. Seredenina, A. Filippova, Sumitra Ramachandran, A. Bridges, L. Chaudry, G. Pettman, C. Allan, Sarah Duncan, Kiew Ching Lee, Jean Lim, May Thu Ma, Agnes B. Ong, Nicole Y. Ye, S. Nasir, Sri Mulyanidewi, C. Aw, Pamela P. Oon, Shihua Liao, D. Li, Douglas G. Johns, Neil D. Miller, Ceri H. Davies, E. Browne, Y. Matsuoka, Deborah W. Chen, V. Jaquet, A. Richard Rutter   +30 more
semanticscholar   +1 more source

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Supramolecular Gels as Active Tools for Reaction Engineering

Angewandte Chemie, EarlyView.
The unique combination of environments within gels, self‐assembled from low‐molecular‐weight gelators, offers the ability to control reactivity in new ways, achieving unique reaction outcomes, leading to the emerging concept of supramolecular gels as nanoreactors. Smart chemical engineering methods enable the use of such gels to fabricate materials and
David K. Smith
wiley   +2 more sources

NADPH Oxidase Deficiency: A Multisystem Approach [PDF]

Oxidative Medicine and Cellular Longevity, 2017
The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes.
Giuliana Giardino, Maria Pia Cicalese, Ottavia Delmonte, Maddalena Migliavacca, Boaz Palterer, Lorenzo Loffredo, Emilia Cirillo, Vera Gallo, Francesco Violi, Claudio Pignata   +9 more
openaire   +4 more sources

From Mechanoelectric Conversion to Tissue Regeneration: Translational Progress in Piezoelectric Materials

Advanced Materials, EarlyView.
This review highlights recent progress in piezoelectric materials for regenerative medicine, emphasizing their ability to convert mechanical stimuli into bioelectric signals that promote tissue repair. Key discussions cover the intrinsic piezoelectric properties of biological tissues, co‐stimulation cellular mechanisms for tissue regeneration, and ...
Xinyu Wang, Sílvio Terra Stefanello, Victor Shahin, Yun Qian   +3 more
wiley   +1 more source

Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea. [PDF]

PLoS ONE, 2011
In rodents, exposure to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is associated with neurobehavioral impairments, increased apoptosis in the hippocampus and cortex, as well as increased oxidant stress and inflammation ...
Deepti Nair, Ehab A Dayyat, Shelley X Zhang, Yang Wang, David Gozal   +4 more
doaj   +1 more source

Multi-functional oxidase-like activity of praseodymia nanorods and nanoparticles [PDF]

Applied Surface Science 2023, 610, 155502
The ability to mimic protein-based oxidase with multi-functional inorganic nanozymes would greatly advance biomedical and clinical practices. Praseodymia (PrOx) nanorods (NRs) and nanoparticles (NPs) have been synthesized using hydrothermal and precipitation methods.
arxiv   +1 more source

The NADPH oxidase Nox4 has anti-atherosclerotic functions.

European Heart Journal, 2015
AIMS Oxidative stress is thought to be a risk for cardiovascular disease and NADPH oxidases of the Nox family are important producers of reactive oxygen species.
C. Schürmann, Flávia Rezende, Christoph Kruse, Yakub Yasar, Oliver Löwe, Christian Fork, B. van de Sluis, Rolf Bremer, N. Weissmann, A. Shah, H. Jo, R. Brandes, K. Schröder   +12 more
semanticscholar   +1 more source