Results 61 to 70 of about 399,078 (208)
Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat. [PDF]
PLoS ONE, 2010 Recent work by our laboratory and others has implicated NADPH oxidase as having an important role in reactive oxygen species (ROS) generation and neuronal damage following cerebral ischemia, although the mechanisms controlling NADPH oxidase in the brain ...
Limor Raz +8 more
doaj +1 more source
JCI Insight, 2022 NADPH oxidase deficiency exacerbates lupus in murine models and patients, but the mechanisms remain unknown. It is hypothesized that NADPH oxidase suppresses autoimmunity by facilitating dead cell clearance via LC3-associated phagocytosis (LAP).
Rachael A. Gordon +11 more
doaj +1 more source
Cholesterol: A modulator of the phagocyte NADPH oxidase activity - A cell-free study
Redox Biology, 2014 The NADPH oxidase Nox2, a multi-subunit enzyme complex comprising membrane and cytosolic proteins, catalyzes a very intense production of superoxide ions O2•−, which are transformed into other reactive oxygen species (ROS).
Rawand Masoud +2 more
doaj +1 more source
Nrf2 regulates ROS production by mitochondria and NADPH oxidase
Biochimica et Biophysica Acta, 2014 Background Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible ...
S. Kovac +5 more
semanticscholar +1 more source
Case Reports in Pediatrics, 2012 Chronic granulomatous disease (CGD) is characterized by inherited immune defects resulting from mutations in the NADPH oxidase complex genes. The X-linked type of CGD is caused by defects in the CYBB gene that encodes gp91-phox, a fundamental component ...
Maria J. Gutierrez +4 more
doaj +1 more source
Analytical Cellular Pathology, 2020 Summary. Oxidative stress is an important factor that is related to endothelial dysfunction. ATP-binding cassette transporter G1 (ABCG1), a regulator of intracellular cholesterol efflux, has been found to prevent endothelial activation in vessel walls ...
Jiahong Xue +5 more
doaj +1 more source
The NADPH Oxidase of Endothelial Cells [PDF]
IUBMB Life, 2000 AbstractThe best known NADPH oxidase is that of phagocytes‐ neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2 ‐ and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADPH oxidases.
openaire +2 more sources
Mediators of Inflammation, 2014 Hyperproliferation and oncogene expression are observed in the mucosa of Helicobacter pylori- (H. pylori-) infected patients with gastritis or adenocarcinoma. Expression of oncogenes such as β-catenin and c-myc is related to oxidative stress.
Eunyoung Byun +3 more
doaj +1 more source
NADPH oxidase-dependent redox signaling in TGF-β-mediated fibrotic responses
Redox Biology, 2014 Uncontrolled fibrosis in organs like heart, kidney, liver and lung is detrimental and may lead to end-stage organ failure. Currently there is no effective treatment for fibrotic disorders.
F. Jiang +3 more
semanticscholar +1 more source
PLoS ONE, 2014 Background and Objectives Blood-brain barrier (BBB) dysfunction is an integral feature of neurological disorders and involves the action of multiple proinflammatory cytokines on the microvascular endothelial cells lining cerebral capillaries.
K. Rochfort +3 more
semanticscholar +1 more source