Results 41 to 50 of about 399,078 (208)
Journal of Pharmacological Sciences, 2009 NADPH oxidase is an enzyme that converts molecular oxygen into reactive oxygen species, which cause severe damage in several organs. Cyclooxygenase (COX)-2 is an inducible enzyme that is important in gastric mucosal defense and repair processes.
Akari Nakagiri, Motonobu Murakami
doaj +1 more source
Cell Host and Microbe, 2014 The Arabidopsis immune receptor FLS2 senses the bacterial flagellin epitope flg22 to activate transient elevation of cytosolic calcium ions, production of reactive oxygen species (ROS), and other signaling events to coordinate antimicrobial defenses ...
Lei Li +11 more
semanticscholar +1 more source
NADPH Oxidase and Cardiac Failure [PDF]
Journal of Cardiovascular Translational Research, 2010 Increases in oxidative stress in the heart play an important role in mediating hypertrophy, apoptosis, fibrosis, mitochondrial dysfunction, and the consequent development of heart failure. Although it has been widely believed that electron leakage from the mitochondrial electron transport chain is the primary source of oxidative stress in the failing ...
Junya, Kuroda, Junichi, Sadoshima
openaire +2 more sources
SIRPα Controls the Activity of the Phagocyte NADPH Oxidase by Restricting the Expression of gp91phox
Cell Reports, 2012 The phagocyte NADPH oxidase mediates oxidative microbial killing in granulocytes and macrophages. However, because the reactive oxygen species produced by the NADPH oxidase can also be toxic to the host, it is essential to control its activity. Little is
Ellen M. van Beek +8 more
doaj +1 more source
Molecules, 2023 Disruption of apoptosis leads to cancer cell progression; thus, anticancer agents target apoptosis of cancer cells. Reactive oxygen species (ROS) induce apoptosis by activating caspases and caspase-dependent DNase, leading to DNA fragmentation.
Ju Won Eom, Joo Weon Lim, Hyeyoung Kim
doaj +1 more source
NADPH Oxidase Activation Contributes to Heavy Ion Irradiation–Induced Cell Death
Dose-Response, 2017 Increased oxidative stress plays an important role in heavy ion radiation–induced cell death. The mechanism involved in the generation of elevated reactive oxygen species (ROS) is not fully illustrated.
Yupei Wang +6 more
doaj +1 more source
Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea. [PDF]
PLoS ONE, 2011 In rodents, exposure to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), is associated with neurobehavioral impairments, increased apoptosis in the hippocampus and cortex, as well as increased oxidant stress and inflammation ...
Deepti Nair +4 more
doaj +1 more source
PLoS ONE, 2016 RationaleObesity is often associated with a state of oxidative stress and increased lipid deposition in the heart. More importantly, obesity increases lipid influx into the heart and induces excessive production of reactive oxygen species (ROS) leading ...
Mohamed Gharib +3 more
doaj +1 more source
Mechanisms of Activation of NADPH Oxidases
Japanese Journal of Infectious Diseases, 2004 The members of the NOX family of enzymes are expressed in a variety of tissues and serve a number of functions. There is a high level of conservation of primary protein sequence, as well as functional features, although specialized responses are beginning to emerge.
Clark, Robert A. +2 more
openaire +2 more sources
NADPH Oxidases in Aortic Aneurysms
Antioxidants, 2022 Abdominal aortic aneurysms (AAAs) are a progressive dilation of the infrarenal aorta and are characterized by inflammatory cell infiltration, smooth muscle cell migration and proliferation, and degradation of the extracellular matrix. Oxidative stress and the production of reactive oxygen species (ROS) have been shown to play roles in inflammatory cell
openaire +3 more sources