Results 31 to 40 of about 399,078 (208)

Khz (fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating JNK and NADPH oxidase-dependent generation of reactive oxygen species. [PDF]

PLoS ONE, 2012
Khz is a compound derived from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia that inhibits the growth of cancer cells. The results of the present study show that Khz induced apoptosis preferentially in transformed cells and had only ...
Tae Hwan Kim, Ju sung Kim, Zoo haye Kim, Ren Bin Huang, Ren Sheng Wang   +4 more
doaj   +1 more source

The roles of NADPH oxidase in modulating neutrophil effector responses

Molecular Oral Microbiology, 2019
Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of a wide variety of effector responses and generation of large amounts of reactive oxygen species (ROS).
M. Zeng, I. Miralda, C. L. Armstrong, Silvia M. Uriarte, J. Bagaitkar   +4 more
semanticscholar   +1 more source

NADPH Oxidase 4

Definitions, 2020
NADPH oxidase 4 (578 aa, ~67 kDa) is encoded by the human NOX4 gene. This protein plays a role as an oxygen sensor in cell differentiation and signal transduction.

semanticscholar   +1 more source

NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy

Journal of Ophthalmology, 2010
Objectives. Using apocynin (inhibitor of NADPH oxidase), and Mitoquinol 10 nitrate (MitoQ; mitochondrial-targeted antioxidant), we addressed the importance of mitochondria versus NADPH oxidase-derived ROS in glucose-induced apoptosis of pericytes ...
Nik M. Mustapha, Joanna M. Tarr, Eva M. Kohner, Rakesh Chibber   +3 more
doaj   +1 more source

Ectopic Expression of an Arabidopsis Calmodulin-Like Domain Protein Kinase-Enhanced NADPH Oxidase Activity and Oxidative Burst in Tomato Protoplasts

Molecular Plant-Microbe Interactions, 2001
Among plant defense responses to pathogen attack, the release of active oxygen species (AOS), termed the oxidative burst, may affect the attacking pathogen and the host plant cells at the infection site, thereby limiting the spread of the pathogen ...
Tim Xing, Xiao-Jing Wang, Kamal Malik, Brian L. Miki   +3 more
doaj   +1 more source

NADPH oxidase in brain injury and neurodegenerative disorders

Molecular Neurodegeneration, 2017
Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in ischemic and traumatic ...
Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, K. Dhandapani, R. Vadlamudi, D. Brann   +6 more
semanticscholar   +1 more source

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease

Redox Biology, 2017
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown.
Varun Chandrashekaran, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Saurabh Chatterjee   +9 more
doaj   +1 more source

NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits

European Journal of Clinical Investigation, 2018
Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they produce large amounts of superoxide anion (O2−.) and ensuing reactive oxygen species (ROS) to kill phagocytized microbes.
S. Belambri, Loïc Rolas, Houssam Raad, M. Hurtado-Nedelec, P. M. Dang, J. El-Benna   +5 more
semanticscholar   +1 more source

NOX4 exacerbates Parkinson’s disease pathology by promoting neuronal ferroptosis and neuroinflammation

Neural Regeneration Research
Parkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a vital role in the death of ...
Zhihao Lin, Changzhou Ying, Xiaoli Si, Naijia Xue, Yi Liu, Ran Zheng, Ying Chen, Jiali Pu, Baorong Zhang   +8 more
doaj   +1 more source

Exercise Training Ameliorates Renal Oxidative Stress in Rats with Chronic Renal Failure

Metabolites, 2022
In patients with chronic kidney disease, exercise training with moderate intensity protects renal function and improves mortality. However, the mechanisms of the renal protective effects of exercise training in chronic kidney disease have not been ...
Seiko Yamakoshi, Takahiro Nakamura, Lusi Xu, Masahiro Kohzuki, Osamu Ito   +4 more
doaj   +1 more source