Results 31 to 40 of about 249,924 (296)

Activation of NADPH oxidase by purine and pyrimidine nucleotides involves G proteins and is potentiated by chemotactic peptides [PDF]

, 1989
Human neutrophils and HL-60 leukaemic cells possess an NADPH oxidase which catalyses superoxide (O2-) formation and is activated by the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe).
Seifert, Roland, Schultz, Günter, Burde, R.   +2 more
core   +1 more source

Neutrophil antimicrobial defense against Staphylococcus aureus. contribution of cathelicidin and the NADPH oxidase [PDF]

, 2009
Neutrophils are among the most important components of the innate immune response, which provides the first line of host defense. The antimicrobial potential of neutrophils has been traditionally divided into either non-oxidative or oxidative ...
Jann, Naja
core   +1 more source

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Klareskog, Lars, Lars Klareskog, Rikard Holmdahl, Kallberg, H, Padyukov, L, Lars Alfredsson, Harald Burkhardt, Padyukov, Leonid, Olsson, Lina, Holmdahl, Rikard, Lina M Olsson, Burkhardt, H, Anna-Karin Lindqvist, Leonid Padyukov, Lindqvist, Anna-Karin,, Burkhardt, Harald, Klareskog, L, Lindqvist, Anna-Karin, Olsson, Lina M., Henrik Källberg, Olsson, Lina,, Källberg, Henrik, Alfredsson, Lars, Alfredsson, L, Lund University., Holmdahl, Rikard,   +25 more
core   +1 more source

NADPH oxidase (NOX) in the heart : the interplay of NOX-derived ROS in β1-integrin-induced survival signalling [PDF]

, 2011
Moderate levels of reactive oxygen species (ROS) act as mediators in cellular signalling processes. An important source of cardiac ROS is the highly expressed NADPH oxidase (NOX) family isoform NOX2. However, little is known about whether NOX-derived ROS
Rosc-Schlüter, Berit Ines
core   +1 more source

NADPH oxidase mediates oxidative stress and ventricular remodeling through SIRT3/FOXO3a pathway in diabetic mice [PDF]

, 2022
Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus.
Meng Yuan, Jiuchun Qiu, Daiqi Liu, Lingling Zhou, Lu Zhou, Pengsha Li, Gary Tse, Xing Liu, Tong Liu, Yue Zhang, Guangping Li   +10 more
core   +1 more source

Ectopic Expression of an Arabidopsis Calmodulin-Like Domain Protein Kinase-Enhanced NADPH Oxidase Activity and Oxidative Burst in Tomato Protoplasts

Molecular Plant-Microbe Interactions, 2001
Among plant defense responses to pathogen attack, the release of active oxygen species (AOS), termed the oxidative burst, may affect the attacking pathogen and the host plant cells at the infection site, thereby limiting the spread of the pathogen ...
Tim Xing, Xiao-Jing Wang, Kamal Malik, Brian L. Miki   +3 more
doaj   +1 more source

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model

Redox Biology, 2019
The activation of NADPH oxidase contributes to dopaminergic neurodegeneration and motor deficits in Parkinson's disease (PD). However, whether NADPH oxidase is involved in non-motor symptoms, especially cognitive dysfunction in PD remains unknown.
Liyan Hou, Fuqiang Sun, Ruixue Huang, Wei Sun, Dan Zhang, Qingshan Wang   +5 more
doaj   +1 more source

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease

Redox Biology, 2017
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown.
Varun Chandrashekaran, Ratanesh K. Seth, Diptadip Dattaroy, Firas Alhasson, Jacek Ziolenka, James Carson, Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Saurabh Chatterjee   +9 more
doaj   +1 more source

Alkalinity of Neutrophil Phagocytic Vacuoles Is Modulated by HVCN1 and Has Consequences for Myeloperoxidase Activity. [PDF]

, 2015
The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole.
Adam P Levine, Michael R Duchen, Peter R. Rich, Anthony W. Segal, Adam P. Levine, de Villiers, S, Anthony W Segal, Simon de Villiers (725764), Peter R. Rich (725765), Michael R. Duchen (49273), Peter R Rich, Levine, AP, Duchen, MR, Simon de Villiers, Michael R. Duchen, Rich, PR, Adam P. Levine (473969), Anthony W. Segal (251124), Segal, AW   +18 more
core   +1 more source

Nrf2 regulates ROS production by mitochondria and NADPH oxidase. [PDF]

, 2015
Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant ...
Dinkova-Kostova, AT, Holmström, Kira M., Stjepana Kovaca, Kovac, S, Plamena R. Angelovaa, Ying Zhangb, Andrey Y. Abramova, Abramov, Andrey Y., Angelova, PR, Zhang, Y, Abramov, AY, Angelova, Plamena R., Kovac, Stjepana, Zhang, Ying, Kira M. Holmströma, Holmström, KM, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T., Albena T   +18 more
core   +1 more source