Results 51 to 60 of about 399,078 (208)

Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum

Journal of Urological Surgery, 2020
Objective:Resistin is an important factor in the pathogenesis of obesity-induced insulin resistance and endothelial dysfunction-mediated cardiovascular system diseases.
Türkan Güngör, Selin Acar, Erkan Kahraman, Ozan Bozkurt, Nergiz Durmuş   +4 more
doaj   +1 more source

NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets

Nature Reviews Cardiology, 2019
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases such as hypertension, aortic aneurysm, hypercholesterolaemia, atherosclerosis ...
Yixuan Zhang, P. Murugesan, Kai Huang, H. Cai   +3 more
semanticscholar   +1 more source

NADPH Oxidases: Progress and Opportunities [PDF]

Antioxidants & Redox Signaling, 2014
From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemistry, the ...
Alejandra, San Martin, Kathy K, Griendling   +1 more
openaire   +2 more sources

Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade

Journal of Neuroinflammation, 2011
Background Reactive oxygen species (ROS), superoxide and hydrogen peroxide (H2O2), are necessary for appropriate responses to immune challenges. In the brain, excess superoxide production predicts neuronal cell loss, suggesting that Parkinson's disease ...
Das Mita, Rachubinski Angela L, Cantu David, Marriott Beth, Thornton Jennifer, Banninger Gregg P, Zawada W Michael, Griffin W Sue T, Jones Susan M   +8 more
doaj   +1 more source

Clarity on the Isoform-Specific Roles of NADPH Oxidases and NADPH Oxidase-4 in Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2016
Atherosclerosis is a complex disease that remains a leading cause of death and disability. The formation of vascular plaques arises from the interaction of dyslipidemia with the altered function of blood vessels and immune cells. The exact cause of atherosclerosis is not known, but from the 1950s onward, oxidative modifications of lipids and proteins ...
David J R, Fulton, Scott A, Barman
openaire   +2 more sources

Inhibition of NADPH oxidase activation in oligodendrocytes reduces cytotoxicity following trauma. [PDF]

PLoS ONE, 2013
Spinal cord injury is a debilitating neurological disorder that initiates a cascade of cellular events that result in a period of secondary damage that can last for months after the initial trauma.
Joshua T Johnstone, Paul D Morton, Arumugam R Jayakumar, Andrea L Johnstone, Han Gao, Valerie Bracchi-Ricard, Damien D Pearse, Michael D Norenberg, John R Bethea   +8 more
doaj   +1 more source

NADPH Oxidase Dependent NLRP3 Inflammasome Activation Plays an Important Role in Lung Fibrosis by Multi-Walled Carbon Nanotubes

Small, 2015
The purpose of this communication is to elucidate the key role of NADPH oxidase in NLRP3 inflammasome activation and generation of pulmonary fibrosis by multi-walled carbon nanotubes (MWCNTs).
Bingbing Sun, Xiang Wang, Zhaoxia Ji, Meiying Wang, Yu-Pei Liao, C. Chang, Ruibin Li, Haiyuan Zhang, A. Nel, Tian Xia   +9 more
semanticscholar   +1 more source

Vascular Functions of NADPH Oxidases [PDF]

Hypertension, 2010
NADPH oxidases belong to a group of enzymes that generate reactive oxygen species (ROS) by electron transfer from NADPH to molecular oxygen. The product of this reaction is the superoxide anion (O2−), which undergoes secondary reactions. O2− inactivates NO to yield peroxynitrite and spontaneously or under catalysis of superoxide dismutases reacts to ...
openaire   +2 more sources

NADPH Oxidase Deficiency: A Multisystem Approach [PDF]

Oxidative Medicine and Cellular Longevity, 2017
The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes.
Giuliana Giardino, Maria Pia Cicalese, Ottavia Delmonte, Maddalena Migliavacca, Boaz Palterer, Lorenzo Loffredo, Emilia Cirillo, Vera Gallo, Francesco Violi, Claudio Pignata   +9 more
openaire   +3 more sources

NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. [PDF]

PLoS ONE, 2013
Infections, microbe sampling and occasional leakage of commensal microbiota and their products across the intestinal epithelial cell layer represent a permanent challenge to the intestinal immune system. The production of reactive oxygen species by NADPH
Boas Felmy, Pascal Songhet, Emma Marie Caroline Slack, Andreas J Müller, Marcus Kremer, Laurye Van Maele, Delphine Cayet, Mathias Heikenwalder, Jean-Claude Sirard, Wolf-Dietrich Hardt   +9 more
doaj   +1 more source