British Journal of Pharmacology, EarlyView.Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang +5 more
wiley +1 more source
The Vascular Function of Resistance Arteries Depends on NADPH Oxidase 4 and Is Exacerbated by Perivascular Adipose Tissue. [PDF]
Antioxidants (Basel)Diaba-Nuhoho P +4 more
europepmc +1 more source
The fight of innate immunity and abnormal cannabinoids against Candida infection
British Journal of Pharmacology, EarlyView.Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori +2 more
wiley +1 more source
Diabetes-associated sleep fragmentation impairs liver and heart function <i>via</i> SIRT1-dependent epigenetic modulation of NADPH oxidase 4. [PDF]
Acta Pharm Sin BGuo Y +12 more
europepmc +1 more source
Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats. [PDF]
Heliyon, 2021 Elhadidy MG +6 more
europepmc +1 more source
Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance
Diabetic Medicine, EarlyView.In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little +7 more
wiley +1 more source
NADPH oxidase 4 deficiency promotes hepatocellular carcinoma arising from hepatic fibrosis by inducing M2-macrophages in the tumor microenvironment. [PDF]
Sci RepKim JY +5 more
europepmc +1 more source
The FEBS Journal, EarlyView.Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells
The FEBS Journal, EarlyView.MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe +5 more
wiley +1 more source