Results 241 to 250 of about 85,856,906 (279)

Shared molecular framework and bidirectional effects of osteoporosis on periodontal disease and dental implant therapy in the elderly

Periodontology 2000, EarlyView.
Abstract Objectives This review synthesizes evidence regarding the prevalence, epidemiological associations, and mechanistic pathways between osteoporosis, periodontal disease, and dental implant therapy. Materials and Methods A literature review was conducted to identify studies focused on: osteoporosis, periodontal disease, and dental implants ...
Samin Sirous, Jaclyn C. Chalmers, Pin‐Ying Li, Yumna Subhani, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Redox‐regulated signalling of adaptations to contractile activity in skeletal muscle: Implications for age‐related muscle weakness

Experimental Physiology, EarlyView.
Abstract Skeletal muscle adaptation to contractile activity is modulated by redox signalling, primarily through reactive oxygen species (ROS) such as hydrogen peroxide (H2O2). Early research framed ROS as deleterious byproducts of exercise, but subsequent studies have established their roles as signalling molecules involved in mitochondrial biogenesis,
Malcolm J. Jackson
wiley   +1 more source

Optimal timing to assess exercise‐induced oxidative stress: A systematic review and meta‐analysis

Experimental Physiology, EarlyView.
Abstract There is a lack of consensus on optimal timing to assess redox biomarkers post‐exercise, limiting methodological standardisation and linking oxidative stress to physiology. We determined optimal post‐exercise oxidative stress assessment times using three redox biomarkers: glutathione, F2‐isoprostanes and protein carbonyls.
Chrysovalantis Stachteas, Nikolaos Georgogiannis, George G. Nastos, Panagiotis N. Chatzinikolaou, Petros C. Dinas, Anastasios A. Theodorou, Vassilis Paschalis, Ioannis S. Vrabas, Antonios Kyparos, Athanasios Z. Jamurtas, Ioannis G. Fatouros, Michalis G. Nikolaidis, Nikos V. Margaritelis   +12 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Molecular regulation of the NADPH oxidase 4

2021
Vascular smooth muscle cell (SMC) de-differentiation with subsequent migration and proliferation into the subendothelial space is central to the progression of cardiovascular diseases. The Nox4 NADPH oxidase (Nox4) is implicated in maintaining the differentiated phenotype of SMC in part through myocardin, a master regulator of SMC gene expression ...
Brandon Michael Schickling, Francis J Miller, Frederick Domann, Paloma Giangrande, Chad Grueter, Justin Grobe   +5 more
openaire   +1 more source

Small-Molecule Inhibitors of NADPH Oxidase 4

Journal of Medicinal Chemistry, 2010
NOX enzymes are the major contributors in many oxidative damage related diseases. Unfortunately, at present no specific NOX inhibitor is available. Here, we describe the discovery and development of novel NOX4 inhibitors. Compound libraries were tested in a cell-based assay as a primary screen, monitoring H2O2 production.
Gábor, Borbély, István, Szabadkai, Zoltán, Horváth, Péter, Markó, Zoltán, Varga, Nóra, Breza, Ferenc, Baska, Tibor, Vántus, Mónika, Huszár, Miklós, Geiszt, László, Hunyady, László, Buday, László, Orfi, György, Kéri   +13 more
openaire   +2 more sources

NADPH oxidase 4-mediating oxidative stress contributes to endometriosis

Journal of Applied Genetics, 2023
NADPH oxidase 4 (NOX4) plays an important role in the regulation of oxidative stress, which is associated with endometriosis. This study aims to investigate the effects of NOX4 in endometriosis and its molecular mechanisms. Clinical specimens were collected, and human endometrial stromal cells (HESCs) were isolated. The knockdown of NOX4 cell lines was
Xiaojie, Wang, Xiaona, Jiang, Xin, Lv, Xinshu, Wang, Aimin, Lin, Yangyang, Li   +5 more
openaire   +2 more sources

NADPH oxidase 4 function as a hydrogen peroxide sensor

The Journal of Biochemistry, 2018
Nox4, a member of the NADPH- and oxygen-dependent oxidoreductases that generate reactive oxygen species (ROS), is widely expressed and constitutively active. To understand better its function and regulation, specific mutations in the Nox4 dehydrogenase (DH) domain were examined for effects on Nox4 oxidase activity.
Yukio, Nisimoto, Hisamitsu, Ogawa, Yuzo, Kadokawa, Shanlou, Qiao   +3 more
openaire   +2 more sources

Novel redox-targets of NADPH oxidase 4

Free Radical Biology and Medicine, 2018
Nox-derived ROS have been implicated in redox-signaling as they can elicit cysteine oxidation in target proteins. Only a limited number of Nox-differentially oxidized proteins have been identified so far and particularly little is known concerning redox-targets of the constitutively active NADPH oxidase Nox4.
Oliver Löwe, Juliana Heidler, Ilka Wittig, Katrin Schröder, Flavia Rezende, Ralf P. Brandes   +5 more
openaire   +1 more source

Naringin ameliorates diabetic nephropathy by inhibiting NADPH oxidase 4

European Journal of Pharmacology, 2017
Naringin, a naturally flavanone glycoside, has been previously demonstrated to alleviate diabetic kidney disease by inhibiting oxidative stress and inflammatory reaction. However, the underlying mechanism of naringin in diabetic nephropathy (DN) has not been fully elucidated. Here, the beneficial effect of naringin on DN in streptozotocin (STZ)-induced
Junwei, Zhang, Suxia, Yang, Huicong, Li, Fang, Chen, Jun, Shi   +4 more
openaire   +2 more sources