MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen +4 more
wiley +1 more source
Role of NADPH Oxidases in Blood-Brain Barrier Disruption and Ischemic Stroke. [PDF]
Antioxidants (Basel), 2022 Hernandes MS, Xu Q, Griendling KK.
europepmc +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang +4 more
wiley +1 more source
MicroRNAs in the Regulation of NADPH Oxidases in Vascular Diabetic and Ischemic Pathologies: A Case for Alternate Inhibitory Strategies? [PDF]
Antioxidants (Basel), 2022 Wallace SR, Pagano PJ, Kračun D.
europepmc +1 more source
Additive effect of polymorphisms in the β2‐adrenoceptor and
, 2014 Tao Wang +5 more
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Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng +6 more
wiley +1 more source
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase [PDF]
, 2007 Sang Won Suh +4 more
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Mass Spectrometry Reviews, EarlyView.ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley +1 more source
NADPH Oxidases in Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction. [PDF]
Antioxidants (Basel), 2022 Teuber JP +4 more
europepmc +1 more source