Results 11 to 20 of about 30,089 (299)
Inhibiting NADPH Oxidases to Target Vascular and Other Pathologies: An Update on Recent Experimental and Clinical Studies [PDF]
Biomolecules, 2022 Reactive oxygen species (ROS) can be beneficial or harmful in health and disease. While low levels of ROS serve as signaling molecules to regulate vascular tone and the growth and proliferation of endothelial cells, elevated levels of ROS contribute to ...
Anthony L. Sylvester +3 more
doaj +2 more sources
Reno-Protective Effect of GLP-1 Receptor Agonists in Type1 Diabetes: Dual Action on TRPC6 and NADPH Oxidases [PDF]
Biomedicines, 2021 Diabetic kidney disease (DKD), a serious diabetic complication, results in podocyte loss and proteinuria through NADPH oxidases (NOX)-mediated ROS production.
Natalie Youssef +7 more
doaj +2 more sources
Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion [PDF]
Antioxidants, 2022 Oxidative stress is critically involved in the pathophysiology of myocardial ischemic-reperfusion (I/R) injury. NADPH oxidase (Nox) 2 and 4, major sources of reactive oxygen species (ROS) in cardiomyocytes, are upregulated in response to I/R. Suppression
Shouji Matsushima, Junichi Sadoshima
doaj +2 more sources
The NADPH Oxidase of Endothelial Cells [PDF]
IUBMB Life, 2000 AbstractThe best known NADPH oxidase is that of phagocytes‐ neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2 ‐ and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADPH oxidases.
Bernard Babior
openalex +5 more sources
NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology [PDF]
Antioxidants, 2021 Annelise Vermot +2 more
exaly +2 more sources
NADPH Oxidase and Neurodegeneration [PDF]
Current Neuropharmacology, 2012 NADPH oxidase (Nox) is a unique, multi-protein, electron transport system that produces large amounts of superoxide via the reduction of molecular oxygen. Nox-derived reactive oxygen species (ROS) are known to be involved in a variety of physiological processes, including host defense and signal transduction.
Marina S. Hernandes, Luiz R.G. Britto
openaire +2 more sources
Redox Biology, 2020 Cardiovascular side effects are frequent problems accompanying systemic glucocorticoid therapy, although the underlying mechanisms are not fully resolved.
Damir Kračun +7 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Metabolic syndrome (MetS), a complex of interrelated risk factors for cardiovascular disease and diabetes, is comprised of central obesity (increased waist circumference), hyperglycemia, dyslipidemia (high triglyceride blood levels, low high-density ...
Hewang Lee, Pedro A Jose, Pedro A Jose
doaj +1 more source
Regulation of Plant NADPH Oxidase [PDF]
Plant Signaling & Behavior, 2007 The production of Reactive Oxygen Species (ROS) is one of the key events occurring during the response of plants to environmental changes, and contributing to establish adaptive signaling pathways. A plasma membrane bound NADPH oxidase enzyme has been evidenced as the ROS producing system in various plant-microorganisms interactions.
Elmayan, Taline, Simon-Plas, Françoise
openaire +4 more sources
NADPH Oxidases in Vascular Pathology [PDF]
Antioxidants & Redox Signaling, 2014 Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play a central role. They are a source of "kindling radicals," which affect other enzymes, such as nitric oxide synthase endothelial nitric oxide synthase or xanthine oxidase.
Tomasz J. Guzik +3 more
openaire +4 more sources