NADPH oxidases in Parkinson’s disease: a systematic review
Molecular Neurodegeneration, 2017 Parkinson’s disease (PD) is a progressive movement neurodegenerative disease associated with a loss of dopaminergic neurons in the substantia nigra of the brain. Oxidative stress, a condition that occurs due to imbalance in oxidant and antioxidant status,
Karim Belarbi +4 more
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The Arabidopsis NADPH oxidases RbohD and RbohF display differential expression patterns and contributions during plant immunity [PDF]
Journal of Experimental Botany, 2016 Plant NADPH oxidases, also known as respiratory burst oxidase homologues (RBOHs), produce reactive oxygen species (ROS) that perform a wide range of functions.
Antonio Molina +6 more
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Role of NADPH Oxidases in Stroke Recovery [PDF]
AntioxidantsStroke is one of the most significant causes of death and long-term disability globally. Overproduction of reactive oxygen species by NADPH oxidase (NOX) plays an important role in exacerbating oxidative stress and causing neuronal damage after a stroke.
Dong-Hee Choi, In-Ae Choi, Jongmin Lee
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NADPH oxidases: Current aspects and tools [PDF]
Redox Biology, 2020 Reactive oxygen species (ROS) have been shown or at least suggested to play an essential role for cellular signaling as second messengers. NADPH oxidases represent a source of controlled ROS formation.
Katrin Schröder
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Inhibition of NADPH Oxidases Prevents the Development of Osteoarthritis [PDF]
Antioxidants, 2022 Increased oxidative stress in osteoarthritis (OA) cartilage mediates catabolic signal transduction leading to extracellular matrix degradation and chondrocyte apoptosis.
Jin Han +3 more
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NADPH oxidases in vascular pathology [PDF]
Antioxidants and Redox Signaling, 2014 Significance: Reactive oxygen species (ROS) play a critical role in vascular disease. While there are many possible sources of ROS, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases play a central role. They are a source of “kindling radicals,”
A. Konior +3 more
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Inhibiting NADPH Oxidases to Target Vascular and Other Pathologies: An Update on Recent Experimental and Clinical Studies [PDF]
Biomolecules, 2022 Reactive oxygen species (ROS) can be beneficial or harmful in health and disease. While low levels of ROS serve as signaling molecules to regulate vascular tone and the growth and proliferation of endothelial cells, elevated levels of ROS contribute to ...
Anthony L. Sylvester +3 more
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Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors. [PDF]
Biomol Ther (Seoul), 2020 Several recent studies have reported that reactive oxygen species (ROS), superoxide anion and hydrogen peroxide (H2O2), play important roles in various cellular signaling networks. NADPH oxidase (Nox) isozymes have been shown to mediate receptor-mediated
Lee SR, An EJ, Kim J, Bae YS.
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The Relationship of NADPH Oxidases and Heme Peroxidases: Fallin' in and Out
Frontiers in Immunology, 2019 Peroxidase enzymes can oxidize a multitude of substrates in diverse biological processes. According to the latest phylogenetic analysis, there are four major heme peroxidase superfamilies. In this review, we focus on certain members of the cyclooxygenase-
Gábor Sirokmány +3 more
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Unraveling the Crosstalk between Lipids and NADPH Oxidases in Diabetic Kidney Disease [PDF]
Pharmaceutics, 2023 Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus and a leading cause of end-stage renal disease. Abnormal lipid metabolism and intrarenal accumulation of lipids have been shown to be strongly correlated with the development ...
Rachel Njeim +2 more
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