Advances in the study of extracellular vesicles of Naegleria fowleri and their role in contact-independent pathogenic mechanisms [PDF]
Parasites & VectorsBackground Extracellular vesicles (EVs) are spherical membrane particles released by prokaryotic and eukaryotic cells. EVs produced by pathogenic organisms are known to play a role in host-pathogen interactions; however, despite some reports on Naegleria
Ismael Castelan-Ramírez +7 more
doaj +4 more sources
Naegleria fowleri from Pakistan Has Type-2 Genotype
Iranian Journal of Parasitology, 2022 Background: Primary amoebic meningoencephalitis (PAM) is an acute and fulminant CNS infection caused by Naegleria fowleri. Recreational activities and ritual ablution with contaminated warm fresh water are the main reason of PAM.
Muhammad Aurongzeb +7 more
doaj +2 more sources
A Fluorometric Assay for the In Vitro Evaluation of Activity against Naegleria fowleri Cysts
Microbiology Spectrum, 2022 Primary amoebic meningoencephalitis (PAM) is a lethal and rapid infection that affects the central nervous system and is caused by the free-living amoeba Naegleria fowleri.
Iñigo Arberas-Jiménez +5 more
doaj +2 more sources
FatalNaegleria fowleriMeningoencephalitis, Italy [PDF]
Emerging Infectious Diseases, 2004 We report the first case of primary amebic meningoencephalitis in Italy, in a 9-year-old boy. Clinical course was fulminant, and diagnosis was made by identifying amebas in stained brain sections and by indirect immunofluorescence analysis. Naegleria fowleri was characterized as genotype I on the basis of polymerase chain reaction test results.
Paola Cogo +8 more
openalex +7 more sources
Detection and identification of Naegleria species along with Naegleria fowleri in the tap water samples [PDF]
BMC Medical GenomicsNaegleria fowleri, the causative agent of Primary Amoebic Meningoencephalitis (PAM), is commonly found in warm freshwater environments and can enter the brain through nasal passages during activities like swimming or ablution.
Muhammad Aurongzeb +7 more
doaj +2 more sources
Enzymatic chokepoints and synergistic drug targets in the sterol biosynthesis pathway of Naegleria fowleri. [PDF]
PLoS Pathogens, 2018 Naegleria fowleri is a free-living amoeba that can also act as an opportunistic pathogen causing severe brain infection, primary amebic meningoencephalitis (PAM), in humans.
Wenxu Zhou +7 more
doaj +3 more sources
Distribution of Naegleria fowleri in Selected Northeast Arkansas Lakes [PDF]
, 1980 Seven northeast Arkansas recreational lakes were examined for the presence of pathogenic and nonpathogenic Naegleria fowleri. Cultural differentiation and microscopic morphology were used as species determining tests, while mouse pathogenicity tests were
Evans, Robert Dean, Hinck, Lawrence W.
core +3 more sources
Potential Inhibitors of Human–Naegleria fowleri Interactions: An In Vitro Extracellular Matrix-Based Model [PDF]
Marine DrugsPrimary amoebic meningoencephalitis (PAM) is a rapidly progressive and fulminant disease that affects the central nervous system caused by the free-living amoeba Naegleria fowleri.
Javier Chao-Pellicer +7 more
doaj +2 more sources
Cyanomethyl Vinyl Ethers Against Naegleria fowleri. [PDF]
ACS Chem Neurosci, 2023 Naegleria fowleri is a pathogenic amoeba that causes a fulminant and rapidly progressive disease affecting the central nervous system called primary amoebic meningoencephalitis (PAM). Moreover, the disease is fatal in more than 97% of the reported cases, mostly affecting children and young people after practicing aquatic activities in nontreated fresh ...
Chao-Pellicer J +7 more
europepmc +3 more sources
Naegleria fowleri: Pathogenesis, Diagnosis, and Treatment Options [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT Naegleria fowleri has generated tremendous media attention over the last 5 years due to several high-profile cases. Several of these cases were followed very closely by the general public. N.
Eddie, Grace, Scott, Asbill, Kris, Virga
exaly +3 more sources