Results 61 to 70 of about 1,770 (171)

Lethal encounters: The evolving spectrum of amoebic meningoencephalitis

IDCases, 2019
The free-living amoebae are thermophilic organisms that may play an increasing role among diseases of a warming world. They are uncommon, accidental, yet high consequence pathogens, with differing pathologic syndromes.
Sandra G. Gompf, Cristina Garcia
doaj   +1 more source

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

PLoS Neglected Tropical Diseases, 2020
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle   +4 more
doaj   +1 more source

Isolation of Naegleria lustrarea n. sp. (Excavata, Discoba, Heterolobosea) from the feces of Ambystoma annulatum (Ringed Salamander) in Northwest Arkansas

Journal of Eukaryotic Microbiology, Volume 71, Issue 4, July/August 2024.
Abstract The salamander, Ambystoma annulatum, is considered a “species of special concern” in the state of Arkansas, USA, due to its limited geographic range, specialized habitat requirements and low population size. Although metazoan parasites have been documented in this salamander species, neither its native protists nor microbiome have yet been ...
Brian M. Becker, Idan Banson, James M. Walker, Anant Deshwal, Matthew W. Brown, Jeffery D. Silberman   +5 more
wiley   +1 more source

A preliminary study on Naegleria species in water bodies of Kurunegala district, Sri Lanka

Sri Lankan Journal of Infectious Diseases, 2018
Introduction and Objective: Species belonging to the genus Naegleria are free-living ubiquitous protozoa. They have been isolated from most regions of the world. N.
JANS Gunarathna, D Iddawela, S Wickramasinghe   +2 more
doaj   +1 more source

Pharmacy Students’ Knowledge Assessment of Naegleria fowleri Infection

Scientifica, 2016
A cross-sectional study was conducted from April to August 2015 to assess the knowledge of pharmacy students towards Naegleria fowleri infection.
Sadia Shakeel, Wajiha Iffat, Madeeha Khan   +2 more
doaj   +1 more source

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri

Frontiers in Microbiology, 2018
Primary amebic meningoencephalitis (PAM) is a fatal infection caused by the free-living ameba Naegleria fowleri, popularly known as the “brain-eating ameba.” The drugs of choice in treating PAM are the antifungal amphotericin B and an antileishmanial ...
Anjan Debnath, Andrew T. Nelson, Angélica Silva-Olivares, Mineko Shibayama, Dionicio Siegel, James H. McKerrow   +5 more
doaj   +1 more source

Identification of Immunogenic Antigens of Naegleria fowleri Adjuvanted by Cholera Toxin

Pathogens, 2020
The intranasal administration of Naegleria fowleri lysates plus cholera toxin (CT) increases protection against N. fowleri meningoencephalitis in mice, suggesting that humoral immune response mediated by antibodies is crucial to induce protection against
Saúl Rojas-Hernández, Mara Gutiérrez-Sánchez, Diego Alexander Rojas-Ortega, Patricia Bonilla-Lemus, Arturo Contis-Montes de Oca, Jorge Herrera-Díaz, Israel López-Reyes, María Maricela Carrasco-Yépez   +7 more
doaj   +1 more source

Agglutination of Naegleria fowleri by Human Serum

Experimental Biology and Medicine, 1982
AbstractThe capability of 154 serum samples from pediatric outpatients and 101 samples from adults to agglutinate amoebae of Naegleria fowleri nN68 was assessed. Sera from all 19 infants tested had an agglutination titer of 1:4 or less; sera of toddlers had a median agglutination titer of 1:8 and those of adults, 1:16. Only 13 of 154 serum samples from
M F, Reilly, M K, Bradley, S G, Bradley
openaire   +2 more sources

Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies

Journal of Extracellular Vesicles, Volume 13, Issue 1, January 2024.
Abstract Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in the brain.
Ursula S. Sandau, Setty M. Magaña, Júlia Costa, John P. Nolan, Tsuneya Ikezu, Laura J. Vella, Hannah K. Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F. Hill, Joseph F. Quinn, Kendall R. Van Keuren‐Jensen, Trevor J. McFarland, Joanna Palade, Eric A. Sribnick, Huaqi Su, Kostas Vekrellis, Beth Coyle, You Yang, Juan M. Falcón‐Perez, Rienk Nieuwland, Julie A. Saugstad, International Society for Extracellular Vesicles Cerebrospinal Fluid Task Force   +22 more
wiley   +1 more source

Glucose metabolism in the pathogenic free‐living amoebae: Tempting targets for treatment development

Chemical Biology &Drug Design, Volume 103, Issue 1, January 2024.
Enzymes involved in glucose metabolism may be promising therapeutic targets for drug development against the pathogenic free‐living amoebae. Details about the enzyme sequence and structural properties make a compelling case for designing small molecule inhibitors that are specific to the amoebae and would not affect the host enzyme.AbstractPathogenic ...
Jillian E. Milanes, Samuel Kwain, Allyson Drawdy, Laura Dodson, Matthew T. Monaghan, Christopher A. Rice, Brian N. Dominy, Daniel C. Whitehead, James C. Morris   +8 more
wiley   +1 more source