Results 131 to 140 of about 176,389 (357)
Food Safety and Health, EarlyView.Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang +3 more
wiley +1 more source
NAFLD as a continuum: from obesity to metabolic syndrome and diabetes
Diabetology & Metabolic Syndrome, 2020 Background The prevalence of non-alcoholic fatty liver disease (NAFLD) has been increasing rapidly. It is nowadays recognized as the most frequent liver disease, affecting a quarter of global population and regularly coexisting with metabolic disorders ...
A. Godoy-Matos +2 more
semanticscholar +1 more source
NAFLD as a driver of chronic kidney disease.
Journal of Hepatology, 2020 Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25-30% (NAFLD), and up to 10-15% (CKD) of the general population.
C. Byrne, G. Targher
semanticscholar +1 more source
Microbial and metabolic impacts of trehalose and trehalose analogues
Gut Microbes, 2020 Trehalose is a disaccharide and fasting-mimetic that has been both canonized and vilified for its putative cardiometabolic and microbial effects. Trehalose analogues are currently under development to extend the key metabolic therapeutic actions of ...
Yiming Zhang, Brian J. DeBosch
doaj +1 more source
NAFLD Preclinical Models: More than a Handful, Less of a Concern?
Biomedicines, 2020 Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and/or hepatocellular carcinoma.
Yvonne Oligschlaeger +1 more
doaj +1 more source
Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Cell Death and Disease, 2020 Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma ...
P. Rada +3 more
semanticscholar +1 more source
Evaluation of liver stiffness measurement–based scores in liver transplantation recipients
Liver Transplantation, EarlyView., 2022 Abstract Combining bioclinical parameters with liver stiffness measurement (LSM) has improved the diagnostic performance of vibration‐controlled transient elastography (VCTE) for detection of advanced fibrosis in patients with chronic liver disease. However, this approach has not yet been tested in liver transplantation (LT) recipients.
Tamoore Arshad +11 more
wiley +1 more source
From nonalcoholic steatohepatitis, metabolic dysfunction-associated fatty liver disease, to steatotic liver disease: Updates of nomenclature and impact on clinical trials [PDF]
Clinical and Molecular Hepatology, 2023 Ming-Lun Yeh, Ming-Lung Yu
doaj +1 more source
High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver
Epigenetics, 2017 High-fat diet consumption and sedentary lifestyle elevates risk for obesity, non-alcoholic fatty liver disease, and cancer. Exercise training conveys health benefits in populations with or without these chronic conditions. Diet and exercise regulate gene
Dan Zhou +9 more
doaj +1 more source
Nicotinamide and NAFLD: Is There Nothing New Under the Sun? [PDF]
, 2019 Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and energy homeostasis. Its importance has been established early with the discovery of NAD's therapeutic role for pellagra.
Maria Guarino +3 more
core +2 more sources